Ryans is considered a frontrunner for the job. NFL insider Ian Rapoport reports that if the second interview goes well, Ryans is expected to become the new head coach in Houston.
The Texans initially interviewed Ryans on January 20, ahead of the 49ers' playoff game against the Dallas Cowboys.
Ryans played linebacker in Houston for six seasons. He has been a part of 49ers head coach Kyle Shanahan's staff since 2017 and has been the team's defensive coordinator for the past two seasons.
Shanahan will likely have to start searching for a new defensive coordinator soon.