Inactives:
- QB Jimmy Garoppolo (foot)
- DL Kevin Givens (knee)
- DB Tarvarius Moore (knee)
- LB Curtis Robinson
- WR Deebo Samuel (ankle, knee)
- CB Samuel Womack (concussion)
- OL Nick Zakelj
The 49ers had already ruled out Garoppolo, Givens, Moore, Samuel, and Womack due to injuries. The team placed defensive lineman Hassan Ridgeway on injured reserve just hours before kickoff. He sustained a pectoral injury during Week 13 against the Miami Dolphins.
Quarterback Brock Purdy was listed as "questionable" due to oblique and rib injuries. As expected, he is active and will start against Seattle.
Defensive lineman Kerry Hyder (ankle) and cornerback Ambry Thomas (ankle) were also listed as "questionable." Both are active.
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