Samuel emerged from Monday night's win over the Arizona Cardinals with a hamstring injury. Although, it wasn't immediately known. And the injury was different than the Week 7 hamstring injury that occurred against the Kansas City Chiefs and kept him out the next week against the Los Angeles Rams.
"No, it was something different," Shanahan responded when asked if the two injuries were related. "We got back at like seven in the morning. I'm sure he went home and slept for a while. It was a little weird day."
While speaking with reporters before Wednesday's practice, the coach wasn't aware of the injury yet.
"He didn't feel it much on Tuesday," Shanahan continued. "Got the information on Wednesday, and then we were safe about it."
The 49ers have listed Samuel as "questionable" for Sunday's game against the Saints. The only other player on Friday's injury report was defensive lineman Arik Armstead, who has been listed as "doubtful" due to foot and ankle injuries.
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