Below are the 49ers-Broncos in-game injury updates.
LB Azeez Al-Shaair (knee, out)
Azeez Al-Shaair left the game with just over four minutes left in the first half. The 49ers announced that he suffered a knee injury and is questionable to return.
Update: Al-Shaair has been ruled out of the remainder of the game. After the game, head coach Kyle Shanahan said the linebacker likely suffered an MCL sprain.
T Trent Williams (ankle, out)
Trent Williams was shaken up in the third quarter on the play that saw quarterback Jimmy Garoppolo throw the football after stepping out of the back of the end zone, resulting in a safety.
The cart was brought out for Williams, but the veteran tackle declined the ride and walked slowly to the locker room with some assistance.
Update: The 49ers later ruled out Williams. After the game, Shanahan said the tackle likely suffered a high-ankle sprain.