Activated from the practice squad
- RB Kerryon Johnson
Placed on injured reserve
- DL Kevin Givens
- RB JaMycal Hasty
Givens and Hasty were injured during the 49ers' Week 2 victory over the Philadelphia Eagles. Both suffered ankle injuries but could return later this season.
San Francisco enters the game with a 2-0 record while Green Bay is 1-1. Kickoff between the two teams is scheduled for 5:20 p.m. from Levi's Stadium. The home-team Niners are currently favored by 3.5 points.