Released or Waived
The first-known source of the news is listed next to each player's name.
- WR Travis Benjamin (J. Anderson)
- C Jake Brendel (NFLN)
- S Ha Ha Clinton-Dix (Orlando Sentinel)
- LB Justin Hilliard (The Athletic)
- FB Josh Hokit (The Athletic)
- OL Senio Kelemete (NFLN)
- TE Jordan Matthews (SF Chronicle)
- CB Alexander Myres (The Athletic)
- TE MyCole Pruitt (NFLN)
- WR Nsimba Webster (The Athletic)
The 49ers later announced the following roster cuts.
- DL Alex Barrett
- WR River Cracraft
- DL Darrion Daniels
- RB Wayne Gallman
- OL Alfredo Gutierrez
- CB Dontae Johnson
- OL Corbin Kaufusi
- S Jared Mayden
- OL Colton McKivitz
- OL Dakoda Shepley
- QB Nate Sudfeld
- LB Elijah Sullivan
- DL Eddie Yarbrough
Reserve/Physically-Unable-to-Perform List
These players will be ineligible to play or practice for the first six weeks of the season.
- DB Tarvarius Moore
- RB Jeff Wilson Jr.
Injured Reserve
- T Shon Coleman
Suspended
- DE Jordan Willis
Traded
LB Jonas Griffith and a 2022 seventh-round draft pick (NFN)
Exchanged for Broncos' 2022 sixth-round draft pick and a 2023 seventh-round draft pick
Key Upcoming Dates
Wednesday, September 1
NFL clubs may claim players who were waived by other teams until 1 p.m. PT.
NFL clubs may begin establishing a practice squad of 16 eligible players. Up to four of those players must not have earned more than two accrued seasons. Up to six can be veterans with an unlimited number of accrued pro seasons.
Sunday, September 12
San Francisco 49ers at Detroit Lions, regular-season opener, Ford Field, Detroit, Michigan at 10:00 a.m. PT
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