Both wide receiver Deebo Samuel and running back Tevin Coleman are ruled out. Neither practiced this week. Two other receivers, River Cracraft and Trent Taylor, are listed as "questionable."
Sunday will be Samuel's third consecutive missed game due to a hamstring injury. He also missed the first three games of the season after suffering a Jones fracture in June.
Head coach Kyle Shanahan noted that cornerback Richard Sherman would not be activated from injured reserve before this weekend's game. The 49ers opened his practice windows this week. Sherman's most-likely return will be on November 29 after the bye week, against the Los Angeles Rams.
"He did a good job," Shanahan explained. "Was able to practice all three days on scout team. If we had to do it, we could push it, but it wouldn't be the smartest thing. So, we're going to take him into this bye week and feel good about him going against the Rams."
Below are the official injury reports for the 49ers and Saints, which were provided by the 49ers Communications staff. Also included are Friday's practice participation reports.
San Francisco 49ers
Out
RB Tevin Coleman (knee), LB Demetrius Flannigan-Fowles (hamstring), WR Deebo Samuel (hamstring), CB K'Waun Williams (ankle)
Questionable
WR River Cracraft (quadricep), WR Trent Taylor (back)
New Orleans Saints
Questionable
RB Dwayne Washington (back)
San Francisco 49ers Friday Practice
Did Not Participate In Practice
RB Tevin Coleman (knee), LB Demetrius Flannigan-Fowles (hamstring), WR Deebo Samuel (hamstring), CB K'Waun Williams (ankle)
Limited Participation in Practice
WR River Cracraft (quadricep)
Full Participation in Practice
WR Trent Taylor (back)
New Orleans Saints Friday Practice
Did Not Participate In Practice
RB Dwayne Washington (back)
Limited Participation in Practice
QB Drew Brees (right shoulder), C Erik McCoy (elbow)
Full Participation in Practice
T Ryan Ramczyk (back), WR Michael Thomas (ankle, hamstring)
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