This nomination comes after the Niners' 36-9 Week 3 victory over the New York Giants.
Aiyuk finished the game with 101 all-purpose yards. The receiver hauled in five passes for 70 yards and carried the football three times for 31 yards and a score during his 56 snaps.
The other award nominees are Cincinnati Bengals quarterback Joe Burrow, Minnesota Vikings receiver Justin Jefferson, Jacksonville Jaguars running back James Robinson, and Los Angeles Chargers quarterback Justin Herbert.
Fans can click here to vote for the 49ers rookie through Friday.
Aiyuk played college football at Arizona State, and the 49ers made him the No. 25 overall pick in April. He has seven catches for 91 receiving yards through two games this season.
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