But, as Mullens showed during his team's dominant 36-9 victory over the Giants, any doubts anyone may have had about his ability to step in and lead the team to a win were completely unfounded.
Mullens had a number of good moments during his time as a starter over the second half of the 2018 season while Garoppolo was sidelined with a torn ACL. He finished that season with three wins in eight games, 2,277 yards passing, 13 touchdowns, and 10 interceptions -- a performance good enough to leave some wondering if he might push for the starting job in 2019 if Garoppolo was unable to bounce all the way back from his injury.
But Garoppolo stayed healthy throughout 2019, which meant Mullens spent almost all of last season on the bench. Mullens' first meaningful game action since 2018 didn't come until he entered last week's 31-13 win over the New York Jets after Garppolo suffered a high ankle sprain, and he finished with a somewhat uninspiring stat line of 71 yards and one interception on 8 of 11 passing.
So, what would Mullens do against the Giants this week? It was a good question coming into the game -- one he answered emphatically by throwing for 343 yards and one touchdown on 25 of 36 passing.
"Nick was great," said 49ers head coach Kyle Shanahan after the win over the Giants. "He was very poised. We went on a lot of long drives today, which they're better than not scoring, but the long drives can get a little bit exhausting, especially for me. I don't want to have to call that many plays. But Nick kept his composure."
Mullens was by no means perfect against the Giants, especially during the first half when he and the offense were moving the ball with effectiveness but didn't reach the end zone until late in the second quarter. In the second half, however, Mullens took a 16-6 halftime lead and helped break it open by hitting on 11 of 12 of his passes after finishing the first half 14 of 24.
"We were moving the ball pretty good but we kind of got some second-and-long situations and had to overcome a lot of stuff to keep it going," Mullens said after the win. "In the second half, those field goals turned to touchdowns, which was huge."
There may have been those who felt Mullens showed more zip on the ball against the Giants than he did in 2018. Shanahan isn't one of them, but he does believe Mullens has improved in other ways, which he was able to show on Sunday.
"It's not a big difference to me," Shanahan said. "He's improved in a lot of areas since his first year. Regardless of his arm strength, he can make every single throw we need him to make. He did a hell of a job of it today. His arm strength with his preparation and everything, that's why he gets the ball in the right spots. When he sees it, he lets it rip. Not only did he execute a lot of stuff today, he made a number of off-schedule plays too."
Mullens told reporters after the game he felt confident after a strong week of preparation and was able to capitalize on his opportunities without hesitation, just as Shanahan said.
"It's kind of what you have to live by... I'm not the fastest, most athletic guy, but I think I can react pretty quick," Mullens said. "That's what I think I do pretty well."
Garoppolo's situation will likely continue to be one that gets monitored on a day-to-day basis, meaning he could be back in the lineup when the 49ers face the Philadelphia Eagles at Levi's Stadium in Santa Clara next Sunday (5:20 p.m. PDT). But Mullens showed there might not be much to worry about if he has to hold down the fort for at least another week, which is something his teammates already knew.
"Nick is who he always is," offensive tackle Mike McGlinchey said after the win over the Giants. "He was a great force for us today. He took command all week, starting from Wednesday on, and he goes out and balls. That's who he is. We're very, very confident in his abilities, his understanding of what we do. He's been in our system for a long time and he's had success when he's been in there."
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