The touchdown came on a 19-yard run in the third quarter and gave the Niners a 23-9 lead.
Aiyuk has three receptions for 39 yards on four targets from quarterback Nick Mullens. The receiver has also carried the football three times for 31 yards and the score.
The 49ers made Aiyuk the second of their two first-round draft picks in April. The rookie missed Week 1 as he continued to recover from a hamstring injury and got his first in-game action last weekend against the New York Jets.
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