They are fullback Kyle Juszczyk (knee), tackle Mike McGlinchey (knee), and cornerback Ahkello Witherspoon (foot).
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The 49ers (7-0) kick off at 5:20 p.m. PT against the Arizona Cardinals (3-4-1) for a Halloween-night matchup at State Farm Stadium.
One other player, tackle Joe Staley (fibula), is also expected to return against the Seahawks. For now, he remains among the inactive players against the Cardinals.
Wide receiver Marquise Goodwin is also a healthy inactive heading into the game, which is somewhat expected. He missed Sunday's game against the Carolina Panthers, too.
Below are the inactive players for San Francisco:
- QB C.J. Beathard
- FB Kyle Juszczyk
- OT Mike McGlinchey
- CB Ahkello Witherspoon
- OT Joe Staley
- WR Marquise Goodwin
- DT Jullian Taylor
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