Bosa finished the game with four combined tackles, two sacks, five quarterback hits, a forced fumble, and a fumble recovery during the 31-3 victory.
The other award nominees are Jacksonville Jaguars quarterback Gardner Minshew, Arizona Cardinals quarterback Kyler Murray, Oakland Raiders running back Josh Jacobs, and Carolina Panthers linebacker Brian Burns.
Bosa does have the advantage of being the only nominated player who played during primetime.
Fans can click here to vote for the 49ers rookie through Friday. Bosa played college football at Ohio State, and the 49ers made him the No. 2 overall pick in April.
Wide receiver Deebo Samuel was the last 49ers player to be nominated for the award, which occurred after Week 2. He did not end up winning.
More San Francisco 49ers News
-
49ers' Nick Bosa offers positive update on ACL recovery and Week 1 status
San Francisco 49ers defensive end Nick Bosa has missed several training camp practices due to soreness and tendinitis in his surgically repaired knee. The pass rusher was limited to just three games last season after suffering a torn ACL, but was medically cleared at the start... -
49ers injury updates: Encouraging news on Christian McCaffrey, Nick Bosa, Mike Evans, others
The San Francisco 49ers took part in a joint practice with the Los Angeles Chargers on Tuesday at the Chargers' practice facility in El Segundo, California. Running back Christian McCaffrey continues to miss practice as he works through some "tightness." McCaffrey has not... -
49ers injury updates: Kyle Shanahan discusses Renardo Green, Nick Martin, others following preseason win over Chargers
The San Francisco 49ers took on three injuries of note during their 41-17 preseason win over the Los Angeles Chargers on Thursday night, according to head coach Kyle Shanahan. Cornerback Renardo Green left the game with a hamstring injury in the first half and did not return.... -
Recap: 49ers win all three phases to cruise to 41-17 preseason win over Chargers
Reports from this week's joint practice between the San Francisco 49ers and Los Angeles Chargers suggested the Chargers had a clear edge, particularly against the 49ers' defense. But when the teams faced off at SoFi Stadium in Inglewood, California on Thursday night, it was...