Breida is up against Tevin Coleman of the Atlanta Falcons and Phillip Lindsay of the Denver Broncos. Coleman had 107 rushing yards in a 31-24 win over the Carolina Panthers while Lindsay recorded 107 yards in a 20-19 victory against the Oakland Raiders.
The 49ers signed Breida, who leads NFL running backs this season with 184 rushing yards, as an undrafted free agent out of Georgia Southern last year. His 66-yard touchdown run on Sunday against Detroit was the longest of his career and the longest for the franchise since a 90-yard run by Colin Kaepernick against the San Diego Chargers in 2014.
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Breida has registered 649 rushing yards on 127 carries over his career with three touchdowns. He also has 25 career receptions for 206 yards and a touchdown. 21 of those receiving yards came on three catches against the Lions on Sunday.