Tight end George Kittle (ankle), wide receiver Trent Taylor (ribs), and defensive end Solomon Thomas (knee) were all inactive for the 49ers' win over the New York Giants on November 12.
"I hope [they can play]," Shanahan said. "I'm expecting them to. They were all pretty limited on Monday. They're going to be limited today. I could tell the week off really helped them. I don't think they would have been able to play last week, but they're practicing. They're still limited, but I'm hoping they'll go."
Taylor and running back Raheem Mostert were in blue no-contact jerseys during Wednesday's practice.
One rookie that did not participate in Wednesday's practice was Adrian Colbert, who suffered a broken thumb against the Giants. Shanahan is not as optimistic about Colbert's chances of playing on Sunday.
"Very small chance," Shanahan said. "We haven't ruled him out yet. We'll see. He'd have to practice a little bit this week, but I'm not feeling too optimistic about that."
Below are the official Wednesday practice participation reports for both the 49ers and Seahawks, as provided by the 49ers Communications department.
San Francisco 49ers Wednesday Practice
Did Not Participate In Practice
S Adrian Colbert (thumb), DE Elvis Dumervil (not injury related), T Joe Staley (not injury related)
Limited Participation in Practice
TE George Kittle (ankle), RB Raheem Mostert (shoulder), WR Trent Taylor (ribs), DE Solomon Thomas (knee)
Full Participation in Practice
DT D.J. Jones (shoulder), LB Elijah Lee (knee), S Eric Reid (knee)
Seattle Seahawks Wednesday Practice
Did Not Participate In Practice
G Oday Aboushi (shoudler), LB D.J. Alexander (shoulder), T Duane Brown (ankle), S Kam Chancellor (neck), WR Amara Darboh (ankle), RB Mike Davis (groin), CB Shaquill Griffin (concussion), CB Jeremy Lane (not injury related), LB Bobby Wagner (hamstring), LB Michael Wilhoite (calf)
Limited Participation in Practice
DT Jarran Reed (hamstring)
Full Participation in Practice
G Luke Joeckel (knee), DE Dion Jordan (neck)
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