The wheel route was one of the 49ers most effective routes in 2011. It was often used as one of Harbaugh and Roman's patented "shot plays," where they intentionally called for a shot down the field. The 49ers ran it out of multiple formations, typically to Vernon Davis.
With rookie outside linebacker Nick Perry seeing his first NFL action I would look for Greg Roman and the 49ers to attack Green Bay's rush-happy OLBs and force them into coverage with the wheel route out of run personnel. Below are a few examples of the 49ers running the wheel route with a high degree of success.
I had to link to albums on an external site due to some technical difficulties. I'd recommend opening the album in a different page and reading along with pictures beside the article.
1. Week 5: Tampa Bay
Alex Smith knows where he's going as soon as the ball is snapped. He play flakes, looks to his left to hold the safety, then throws the ball to Davis and earns the PI call against an under-matched linebacker.
Week 9: Washington
This is another shot play on first down immediately after a turnover. In this package the 49ers are looking to sell the run hard. It's 22 personnel (two RBs and two TEs) and both tight ends line up on the right side giving a "tackle over" look. Fullback Bruce Miller goes in motion and at the snap the right to simulate the run action, but more importantly to get him into position to run the wheel route.
At the snap, Braylon Edwards runs the interference route, allowing Miller to come in behind him. The play action freezes the single high safety as well as the linebacker assigned to cover Miller. If the throw wasn't there, Harbaugh knew he had at least a field goal so had Miller not been open Smith would have thrown it away.