Game Day: San Francisco 49ers at New York Giants

Tonight, the New York Giants (2-2) will host the San Francisco 49ers (1-3) at MetLife Stadium in East Rutherford, New Jersey. This marks San Francisco's lone game against an NFC East opponent this season.

The 49ers are coming off of a 17-3 defeat against the Green Bay Packers. The Giants are coming off of a 24-10 victory against the Buffalo Bills.

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The 49ers have lost their last three games. In those losses, they have been outscored 107-28. The 49ers, who are the NFL's lowest-scoring offense, have not scored a touchdown in the past six quarters of play.

QB Colin Kaepernick, playing behind one of the worst offensive lines in the league, has a 67.7 passer rating on the season and a 25.7 rating over the last two weeks. That includes a career low 16.7 rating that he suffered during week three against the the Arizona Cardinals.

Of the quarterbacks that have at least 60 passes, Kaepernick ranks second to last through four games according to Football Outsiders.

The 49ers have had one of the toughest schedules in the NFL through four weeks of play, and it will not be getting any easier. They hope to avoid their worst road losing streak in more than five years. The Giants are looking to win their third straight game after dropping their first two. QB Eli Manning has completed 62.9% of his passes for 976 yards, seven touchdowns and only one interception.

LB Ahmad Brooks will miss the game due to a death in the family. TE Vernon Davis will miss his second straight game with a knee injury. He did not play in last week's loss to the Packers. WR Quinton Patton (concussion) and T Joe Staley (knee) are questionable.

G Andrew Tiller was promoted from the practice squad on Saturday. To make room for him, the 49ers released CB Shareece Wright, who was vocal about the team's refusal to play him and wanted out of San Francisco.

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Update:

The 49ers inactives against the Giants are WR DeAndrew White, RB Mike Davis, LB Gerald Hodges, LB Ahmad Brooks, OL Ian Silberman, NT Mike Purcell, and TE Vernon Davis. That means both Tiller and Staley will suit up for the 49ers.

Kickoff: Sunday, October 11 at 5:30 PM PT

Television: The game will be televised nationally on NBC

Bay Area Radio: KGO 810 & The Bone 107.7 (Other radio affiliates)

Spanish Radio: KTRB 860

Australian Radio: Triple M

All-Time Matchup: Series is tied 19-19

Last Meeting: 11/16/14, 49ers win 16-10, at NYG

Current Streak: Won 1

Betting: The Giants are 6.5 point favorites.

NFL Fan Picks: 75% pick the Giants to win according to Yahoo! Sports

49ers Fan Picks: Within our Pick 'em Contest, 58% believe the Giants will win

49ers Schedule: View full schedule

Giants News: Giants news at Problitz.com

Follow Game Online: NFL.com's Game Center

Discuss: Niner Talk forum

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Injury Report

Team	Pos	Player	Injury	Status
49ers	LB	Ahmad Brooks	Not injury related	Out
49ers	TE	Vernon Davis	Knee	Out
49ers	WR	Quinton Patton	Concussion	Questionable
49ers	T	Joe Staley	Knee	Questionable
49ers	G	Alex Boone	Shoulder, ankle	Probable
49ers	LB	NaVorro Bowman	Not injury related	Probable
49ers	S	L.J. McCray	Knee	Probable
49ers	TE	Vance McDonald	Chest	Probable
Giants	DE	Robert Ayers Jr.	Hamstring	Out
Giants	WR	Victor Cruz	Calf	Out
Giants	LB	Devon Kennard	Hamstring	Out
Giants	DE	George Selvie	Calf	Out
Giants	LB	Jonathan Casillas	Calf	Questionable
Giants	CB	Jayron Hosley	Concussion	Questionable
Giants	CB	Trumaine McBride	Groin	Questionable
Giants	TE	Jerome Cunningham	Knee	Probable

Game Averages (Rank)

49ers		Giants
12.0 (32nd)	Offense Pts	25.5 (9th)
289.0 (31st)	Offense Yds	335.8 (21st)
158.8 (32nd)	Offense Pass	242.8 (19th)
130.2 (5th)	Offense Rush	93.0 (24th)
27.5 (28th)	Defense Pts Allowed	20.5 (11th)
377.2 (23rd)	Defense Yds Allowed	386.0 (26th)
263.2 (21st)	Defense Pass Allowed	316.2 (32nd)
114.0 (21st)	Defense Rush Allowed	69.8 (1st)