The San Francisco 49ers host the Seattle Seahawks in a matchup of NFC West foes on Thursday Night Football. The overall series between the teams is tied at 13 games a piece, with the 49ers winning each of the last 3 contests. This week's game also marks the 49ers 8th Thursday Night game in franchise history. San Francisco has posted a 5-2 record, including 2-0 at home, in these prime time matchups.

Last week, the 49ers (4-2) fell to the New York Giants 26-3. With 75 reception yards on the day, WR Randy Moss (15,032) became just the fourth player in NFL history to surpass 15,000 career reception yards. He trails WR Jerry Rice (22,895), WR Terrell Owens (15,934) and WR Isaac Bruce (15,208) for the most receiving yards in NFL history.

Under head coach Jim Harbaugh, the 49ers have posted a 4-0 record in games following a loss. The 49ers are one of five teams (Atlanta - 6-0; Baltimore - 5-0; Green Bay - 4-0; Pittsburgh - 6-0) to post a perfect record following a loss since 2011. The 49ers are 9-2 at home, 12-4 against the NFC and 5-1 against the NFC West during the Harbaugh era.

The Seahawks (4-2) are coming off of a 24-23 win over the New England Patriots.

The game kicks off at 5:20 PM PT and, as usual, you can visit 49erswebzone.com for the latest news and updates during and after the game.

The game will be televised on NFL Network. The radio broadcast of the game will be on KGO 810 AM and The Bone 107.7 FM.

Within our 2012 NFL Pick 'Em Contest, 96% of fans fans believe that the 49ers will win this game.

Within Sportstacular, a popular mobile phone scores application, 81% of fans believe that the 49ers will win this game.

You can follow the game live on NFL.com's Game Center.

You can also discuss the game with fans in the 49erswebzone.com forums.

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