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Kicking off 2012, the 12-3 San Francisco 49ers will travel to face the 2-13 division rival St. Louis Rams at the Edward Jones Dome in St. Louis, Missouri.
The 49ers are coming off of a 19-17 win over the Seattle Seahawks while the Rams are coming off of a 27-0 loss to the Pittsburgh Steelers.
A 49ers victory would clinch a first round bye in the playoffs for San Francisco.
The game kicks off at 10:00 AM and, as usual, you can visit 49erswebzone.com for the latest news and updates during and after the game.
The game will be televised on FOX.
In the 49erswebzone.com Pick 'Em Contest, 99% of 49ers fans believe that the 49ers will win this game.
Within Sportstacular, a popular mobile phone scores application, 92% of fans believe that the 49ers will win this game.
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