The 49ers are coming off of a 13-8 win over the Cincinnati Bengals while the Eagles are coming off of a 29-16 loss to the New York Giants.
The game kicks off at 10:00 AM and, as usual, you can visit 49erswebzone.com for the latest news and updates during and after the game.
The game will be televised on FOX.
In the 49erswebzone.com Pick 'Em Contest, 52% of 49ers fans believe that the Eagles will win this game.
Within Sportstacular, a popular mobile phone scores application, 63% of fans believe that the Eagles will win this game.
You can follow the game live on NFL.com's Game Center.