Neither team got into the end zone during their Week 1 defeats. The San Francisco 49ers lost big at home to the Carolina Panthers by the score of 23-3. The Seattle Seahawks traveled to Green Bay and fell 17-9. Both teams head into a Week 2 matchup against each other seeking their first victory and the oddsmakers strongly believe that the Seahawks will be the ones to earn their first victory – by a large margin.

Seattle is a heavy 14-point favorite over San Francisco as of Tuesday afternoon, according to Yahoo! Sports. They are as low as 12.5-point favorites, according to other sources, which is still a pretty large margin. It is the second-largest spread of Week 2. The Oakland Raiders are 15-point favorites over the New York Jets.

The 49ers and Seahawks matchup features an over/under set at 43 points.

The 49ers will be without exciting rookie linebacker Reuben Foster, who suffered a high-ankle sprain against Carolina. Following the game, Foster was convinced he would play against Seattle. He even campaigned to return to Sunday's game following his injury. Foster will now miss a month or more, according to 49ers head coach Kyle Shanahan.

The 49ers own a seven-game losing streak against the Seahawks going back to the NFC Championship of the 2013 season. In those games, the combined score has been 170-84. It will be a tough road game for first-year head coach Shanahan, who looks to rebound from Week 1's loss and possibly rekindle what was once one of the fiercest rivalries in the NFL.

The 49ers and Seahawks kick off at CenturyLink Field on Sunday, September 17 at 1:25 p.m. PT.