Mike Davis will likely replace Hyde as the starting running back against the Buccaneers. Shaun Draughn is the other running back on the roster. Expect the 49ers to promote either DuJuan Harris or rookie Kelvin Taylor from the practice squad and have three running backs active for Sunday.
To go along with the 49ers' top running back, the Buccaneers will also be without their own. RB Doug Martin has been ruled out with a hamstring injury.
WR Torrey Smith is questionable due to a back injury. Following some frustrating performances this season with Blaine Gabbert as the team's quarterback, Smith contributed 76 yards and a touchdown with Colin Kaepernick in there during Sunday's loss to the Buffalo Bills.
CB Rashard Robinson is also listed as questionable as he recovers from a concussion suffered against the Bills. He has been limited in practice this week.
San Francisco 49ers Injuries
Out
RB Carlos Hyde (shoulder)
Questionable
DT Glenn Dorsey (knee), CB Rashard Robinson (concussion), WR Torrey Smith (back)
Tampa Bay Buccaneers Injuries
Out
DE Robert Ayers (ankle), RB Doug Martin (hamstring), DT Clinton McDonald (hamstring)
Questionable
CB Jude Adjei-Barimah (knee), C Joe Hawley (knee), DT Gerald McCoy (calf), WR Cecil Shorts (hamstring), TE Luke Stocker (ankle)
San Francisco 49ers Friday Practice
Did Not Practice
K Phil Dawson (illness), RB Carlos Hyde (shoulder)
Limited Participation
DT Glenn Dorsey (knee), CB Rashard Robinson (concussion), WR Torrey Smith (back)
Full Participation
DT Arik Armstead (shoulder), G Zane Beadles (ankle), DT DeForest Buckner (foot), DT Quinton Dial (knee), QB Blaine Gabbert (back), G Joshua Garnett (foot), WR Jeremy Kerley (ankle), TE Vance McDonald (hip), S Jaquiski Tartt (quadricep), CB Jimmie Ward (quadricep)
Tampa Bay Buccaneers Friday Practice
Did Not Practice
DE Robert Ayers (ankle), RB Doug Martin (hamstring)
Limited Participation
DT Gerald McCoy (calf), DT Clinton McDonald (hamstring)
Full Participation
CB Jude Adjei-Barimah (knee), C Joe Hawley (knee), WR Cecil Shorts (hamstring), TE Luke Stocker (ankle)
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