Bryant suffered a hairline fracture near his knee last weekend. He was listed as questionable on Friday's injury report.
The 49ers will be without TE Vance McDonald (hip) and CB Jimmie Ward (quad) as the face the visiting Cowboys.
San Francisco 49ers Inactives
QB Christian Ponder
WR Keshawn Martin
CB Jimmie Ward
DT Tony Jerrod-Eddie
OL John Theus
TE Vance McDonald
DT Taylor Hart
Dallas Cowboys Inactives
QB Tony Romo
CB Orlando Scandrick
RB Darius Jackson
Lab Mark Nzeocha
OG La'el Collins
OT Tyron Smith
WR Dez Bryant.
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