The 49ers will play the NFC South and AFC East, six games within the NFC West, and the last place teams within the NFC.
| Home | Away |
| Dallas Cowboys | Atlanta Falcons |
| New England Patriots | Carolina Panthers |
| New Orleans Saints | Buffalo Bills |
| New York Jets | Miami Dolphins |
| Tampa Bay Buccaneers | Chicago Bears |
| Arizona Cardinals | Arizona Cardinals |
| Seattle Seahawks | Seattle Seahawks |
| St. Louis Rams | St. Louis Rams |
The actual dates and times of each game will be known once the complete NFL schedule is released sometime in April.
Of course, who knows who their head coach will be once that season begins? The 49ers are expected to part ways with head coach Jim Tomsula following the team's season finale against the St. Louis Rams at Levi's Stadium.
More San Francisco 49ers News
-
49ers vs. Cardinals injury updates: Latest news from Week 3 matchup
The San Francisco 49ers are facing the Arizona Cardinals in a Week 3 matchup at Levi's Stadium in Santa Clara, California. Below are the latest in-game injury updates for the 49ers. This article will be updated in real time as new information becomes available. Players are... -
Christian McCaffrey reveals what made the 49ers feel different from the start
Running back Christian McCaffrey immediately knew something was different about the San Francisco 49ers when he arrived via a trade in 2022. That's not a knock on his former team, the Carolina Panthers, where McCaffrey spent his first five-and-a-half NFL seasons. The 49ers had... -
49ers QB Brock Purdy named NFC Offensive Player of the Week after big game vs. Dolphins
San Francisco 49ers quarterback Brock Purdy has been named the NFC Offensive Player of the Week following a standout performance against the Miami Dolphins in Week 2. NFC Players of the Week! (Week 2) @brockpurdy13 | @DevinLloyd_ | @rodgers_isaiah pic.twitter.com/JzV8Me5BDe—... -
49ers vs. Cardinals in Week 3: How to watch, stream, and listen, plus odds
The San Francisco 49ers take on the Arizona Cardinals for their second of three consecutive home games at Levi's Stadium. This matchup marks the 70th meeting between the two clubs, with San Francisco leading the series 38-31 and looking to improve to 22-15 at home. Previous...