Hyde is recovering from a stress fracture in his left foot that has plagued him for much of the season and caused him to miss numerous games. He has not practiced with the team since their last meeting with the Seahawks on October 22. This will be the third straight game that Hyde has missed and head coach Jim Tomsula would not comment on his status going forward.
According to Tomsula, RB Shaun Draughn will make a second consecutive start for the team. Against the Atlanta Falcons, Draughn had 58 yards on 16 carries. He also added 38 yards on four receptions.
WR Anquan Boldin, who is recovering from a hamstring injury, was listed as questionable to play on Sunday.
CB Kenneth Acker has cleared the concussion protocol. He has started eight of the 49ers' nine games this season.
San Francisco 49ers
Out: RB Carlos Hyde (foot)
Questionable: WR Anquan Boldin (hamstring)
Probable: CB Kenneth Acker (concussion, chest), LB NaVorro Bowman (shoulder), CB Tramaine Brock (shin), LB Ahmad Brooks (shoulder), QB Colin Kaepernick (left shoulder), CB Keith Reaser (ankle), S Eric Reid (chest)
Seattle Seahawks
Out: LB Bruce Irvin (knee), WR Paul Richardson (hamstring)
Questionable: RB Marshawn Lynch (abdomen)
Probable: WR Doug Baldwin (toe), DE Michael Bennett (not injury related), DE Demarcus Dobbs (shoulder), DE Cliff Avril (ankle), LB K.J. Wright (knee), T Russell Okung (toe/ankle), TE Luke Willson (toe), CB Cary Williams (hip)
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