Colin Kaepernick has replaced Alex Smith.
The 49ers trail the Rams 14-7.
More San Francisco 49ers News
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49ers injury update: Key starter exits Chargers preseason game
49ers lose a starting cornerback to a hamstring injury during Thursday night's preseason matchup against the Chargers. The San Francisco 49ers face the Los Angeles Chargers at SoFi Stadium in Week 2 of the 2026 NFL preseason. Here is the latest 49ers injury news from the... -
49ers injury updates: Kurtis Rourke taken to the hospital, other news after Titans game
San Francisco 49ers quarterback Kurtis Rourke was playing well in Thursday night's preseason opener against the Tennessee Titans. However, he was forced to leave the game in the second quarter with a rib injury and was replaced by Adrian Martinez. Head coach Kyle Shanahan... -
49ers injury updates: Kyle Shanahan discusses Renardo Green, Nick Martin, others following preseason win over Chargers
The San Francisco 49ers took on three injuries of note during their 41-17 preseason win over the Los Angeles Chargers on Thursday night, according to head coach Kyle Shanahan. Cornerback Renardo Green left the game with a hamstring injury in the first half and did not return.... -
Pablo Torre Investigates the 49ers Substation-Injury Theory
For years, sports journalist Pablo Torre was probably best known to fans for his work at ESPN, where he appeared across the network on shows like Around the Horn and Highly Questionable. More recently, however, Torre has carved out a very different, and increasingly...