Week 1 - Chicago Bears at San Francisco 49ers
Week 2 - San Francisco 49ers at Oakland Raiders
Week 3 - San Francisco 49ers at Dallas Cowboys
Week 4 - San Diego Chargers at San Francisco 49ers
Exact dates and times will be released at a later date.
More San Francisco 49ers News
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Ex-49ers LB highlights practice intensity shift after leaving San Francisco
The San Francisco 49ers endured another injury-plagued campaign in 2025. Despite the setbacks, the team still won 12 games and reached the postseason, leaving many to wonder how much further it could have advanced had several key contributors remained healthy. As injuries have... -
49ers WR Kendrick Bourne opens up about his future in San Francisco
Kendrick Bourne cherished his return to the San Francisco 49ers this season. After all, it was the organization and city where his NFL journey began, when he signed as an undrafted free agent in 2017. While Bourne's overall numbers were modest—finishing with 551 receiving... -
49ers mailbag: Will SF trade Mac Jones? Is there anything to electrical substation talk? Will 49ers be spenders in free agency?
Can't get enough of the San Francisco 49ers? We can help with that. We're back with a brand-new 49ers Webzone Mailbag. We asked for your best 49ers questions, and you came through with several good ones. Thank you for submitting those. Before we jump into the mailbag, be sure... -
49ers could play two international games in 2026—and not everyone is happy
The NFL announced on Thursday that the San Francisco 49ers will face the Los Angeles Rams in the first-ever NFL regular-season game in Melbourne, Australia. The matchup is expected to take place in Week 1, though the official date has not yet been announced. The Australia game...