The 49ers are coming off of a 48-3 win over the Tampa Bay Buccaneers while the Lions are coming off of a 24-13 win over the Chicago Bears.
The game kicks off at 10:00 AM and, as usual, you can visit 49erswebzone.com for the latest news and updates during and after the game.
The game will be televised on FOX.
In the 49erswebzone.com Pick 'Em Contest, 72% of 49ers fans believe that the 49ers will win this game.
Within Sportstacular, a popular mobile phone scores application, 68% of fans believe that the Lions will win this game.
You can follow the game live on NFL.com's Game Center.
You can also discuss the game with fans in the 49erswebzone.com forums.
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