Quarterback Troy Smith makes the start in favor of Alex Smith. Troy Smith led the team to their overtime win over the Rams during their first meeting this season in San Francisco.
The game kicks off at 10:00 am and, as usual, you can visit 49erswebzone.com for the latest news and updates during and after the game.
The game will be aired on FOX.
Within our NFL Pick 'em Contest, 67% of fans believe that the 49ers will win this game.
Within Sportstacular, a popular mobile phone scores application, 42% of fans believe that the 49ers will win this game.
You can follow the game live on NFL.com's Game Center.
You can also discuss the game with fans in the 49erswebzone.com forums.
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