Alex Smith started for the 49ers in place of quarterback Troy Smith. He completed 17 of his 27 passes for 255 yards, three touchdowns and no interceptions.
On the other side of the ball, Seattle quarterback Matt Hasselbeck threw four interceptions.
San Francisco has a short week coming up with a Thursday game against the Chargers in San Diego at Qualcomm Stadium. The 49ers will then finish in St. Louis and at home against Arizona.
View gameday stats at NFL.com's Game Center.
You can also discuss the game with fans in the 49erswebzone.com forums.
More San Francisco 49ers News
-
49ers must prioritize workload management as Super Bowl hopes come into focus
Following a successful, albeit limited, trade deadline, the San Francisco 49ers now face another important challenge as they look to maintain their position among the NFC's elite teams. At 7-1, the 49ers have established themselves as legitimate Super Bowl contenders, but... -
49ers get help from Bills in NFC playoff race
And then there were two. The San Francisco 49ers and Buffalo Bills are now the only teams in the NFL with one loss after Buffalo knocked off the Minnesota Vikings 23-6 on Monday night. The 49ers are coming off a 38-17 victory over the Las Vegas Raiders, improving their record... -
Former 49ers quarterback joins NFC West rival Seahawks
The Seattle Seahawks have added a former San Francisco 49ers quarterback to their roster. According to NFL Network's Mike Garafolo, Seattle has signed Adrian Martinez to its practice squad. The #Seahawks signed former #49ers and #Jets QB Adrian Martinez to the practice squad.... -
49ers Stock Watch: Which Players Are Trending Up and Down?
The San Francisco 49ers are off to a strong start to the 2026 season. While some players have taken advantage of increased opportunities and established themselves as important pieces of the roster, others have seen their production or playing time become a concern. With the...