Smith was 12 of 19 for 196 yards and a touchdown. Running back Frank Gore rushed for 118 yards on 29 carries and a touchdown.
The 49ers enter their bye week and will next face the St. Louis Rams at home on Sunday, November 14.
View gameday stats at NFL.com's Game Center.
You can also discuss the game with fans in the 49erswebzone.com forums.
More San Francisco 49ers News
-
Robert Saleh reveals where 49ers must improve to beat Seahawks
The first time the San Francisco 49ers faced the Seattle Seahawks this season, they opened the year with a 17-13 victory. The rematch didn't come until Week 18, with the NFC's No. 1 seed on the line—and the result was far different. Seattle handled San Francisco 13-3 at... -
Who will the 49ers play if they beat the Eagles?
Two NFC Wild Card games are already in the books, with the Los Angeles Rams (defeated the Carolina Panthers) and the Chicago Bears (defeated the Green Bay Packers) advancing to the NFC Divisional Playoff round. If the San Francisco 49ers pull off an upset over the Philadelphia... -
49ers' Kyle Shanahan explains Brock Purdy's remarkable success in Seattle
San Francisco 49ers quarterback Brock Purdy earned his first career road start in 2022 with a 21-13 win over the Seattle Seahawks at Lumen Field. Since then, he has played three additional games in one of the loudest and most challenging environments in the NFL — and won all... -
49ers Notebook: Veterans praise rookie performance in 2025; Shanahan speaks on Renardo Green scolding; Trent Williams, others reflect on 2025
The mood could have been worse among San Francisco 49ers players Saturday night following their 41-6 season-ending drubbing at the hands of the Seattle Seahawks. But it wasn't, due in part to the reflections that were made on what the team accomplished in 2025 and what lies...