The game kicks off at 5:30 pm and as usual, you can visit 49erswebzone.com for the latest news and updates during and after the game.
Within our NFL Pick 'em Contest, 41% of fans believe that the 49ers will win this game.
Within Sportstacular, a popular mobile phone scores app, 20% of fans believe that the 49ers will win this game.
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More San Francisco 49ers News
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49ers playoff picture: Where San Francisco stands after win over Colts
The San Francisco 49ers extended their winning streak to five games with a 48-27 victory over the Indianapolis Colts on Monday night, building momentum as they head into the postseason. San Francisco had already clinched a playoff berth Sunday when the Pittsburgh Steelers... -
49ers in Week 17 power rankings: Where San Francisco stands after big win vs. Colts
The San Francisco 49ers extended their winning streak to five games on Monday night, defeating the Indianapolis Colts 48-27 on the road. With momentum on their side, the 49ers aim to carry that energy into their final two regular-season games and the playoffs. San Francisco... -
49ers in Week 16 power rankings: Experts cautiously optimistic about San Francisco
The San Francisco 49ers extended their winning streak to four games with a 37-24 victory over the Tennessee Titans on Sunday. The win improved San Francisco's record to 10-4, though the team still trails the Los Angeles Rams and Seattle Seahawks—both 11-3—in the tightly... -
49ers playoff scenarios: How San Francisco can clinch a berth in Week 16
The San Francisco 49ers (10-4) enter Week 16 as 5.5-point favorites against the Indianapolis Colts, aiming to extend their winning streak to five games as they push toward a return to the NFL postseason. With a victory on Monday night at Lucas Oil Stadium, the 49ers would...