Previous game
The 49ers are coming off a 27-7 victory over the Los Angeles Rams in Melbourne, Australia. On offense, QB Brock Purdy completed 25 of 34 passes for 205 yards and three touchdowns. WR Demarcus Robinson caught two passes for a team-high 50 yards and a touchdown, while WR Mike Evans caught six for 49 yards and a touchdown. WR Deebo Samuel Sr. added six catches for 48 yards and a touchdown. RB Christian McCaffrey notched 10 carries for 68 yards and five receptions for 20 yards, while rookie RB Kaelon Black registered 14 carries for 65 yards in his NFL debut.
Defensively, San Francisco held the Rams to just seven points and forced two takeaways. LB Fred Warner led the defense with 11 tackles, one pass defensed, and one forced fumble recovered by DL Keion White. CB Renardo Green tallied three tackles and intercepted Rams QB Matthew Stafford.
The 49ers Communications staff provided the above breakdown.
Below is everything you need to know to follow the upcoming game.
When does the game start?
Sunday, September 20 at 1:25 p.m. PT
Where is the game being played?
Levi's Stadium in Santa Clara, California
Who are the head coaches?
49ers: Kyle Shanahan
Dolphins: Jeff Hafley
Betting Odds
As of September 16, the 49ers are favored by 13.5 points in this game, with an over/under set at 45.5 points, per BetMGM.
What channel is the game on?
Network: FOX
Play-by-Play: Kevin Kugler
Color Analyst: Daryl Johnston
Sideline Reporter: Allison Williams
Viewers outside the broadcast area can watch the game via NFL Sunday Ticket on YouTube TV or YouTube Premium, but they need a subscription to the package.
What areas will receive the broadcast?
The broadcast will be viewable within the markets designated below for those without NFL Sunday Ticket.
Coverage map courtesy of 506sports.com
Where can I stream the game?
NFL Sunday Ticket subscribers can stream the game using the YouTube TV app. Those who purchased through YouTube Premium can watch via the YouTube app. Additionally, NFL+ subscribers can stream the full game once the matchup is complete.
Bay Area fans can stream the game through the official 49ers app or at 49ers.com.
Where can I listen to the radio broadcast?
49ers Radio
Bay Area fans can listen on KGO 810 AM and The Bone 107.7 FM, where Guy Haberman and Tim Ryan will call the game.
Jesús Zárate and Carlos Yustis will call the game in Spanish. Fans can listen at 49ers.com/esp.
Dolphins Radio
Miami-area fans can listen on BIG 105.9 FM (WBGG) and Sports 940 AM (WINZ), where Jimmy Cefalo and Joe Rose will call the game.
Streaming
NFL+ subscribers can listen to the game through that service.
Game discussion
Fans can discuss the game within our Niner Talk forum.
How has this series played out historically?
Matchups: 16
Series Record: Dolphins lead series 9-7
49ers Home Record vs. Dolphins: Series is tied 4-4
49ers Away Record vs. Dolphins: Dolphins lead series 5-2
First Meeting: 9/16/73, Dolphins win 21-13, at Mia.
Last Meeting: 12/22/24, Dolphins win 29-17, at Mia.
Current Streak: Lost 1
Longest 49ers Win Streak: 5 (1/20/85 – 12/16/01)
Longest Dolphins Win Streak: 4 (9/16/73 – 11/6/83)
Most 49ers Points: 44 (11/20/95): 49ers win 44-20, at Mia.
Most Dolphins Points: 43 (10/11/20): Dolphins win 43-17, at SF
49ers Shutouts: 1 (12/16/01): 49ers win 21-0, at SF
Dolphins Shutouts: None
49ers Notes
- QB BROCK PURDY completed 25 of 34 attempts (73.5 pct.) for 205 yards and 3 TDs with a 105.6 rating and added 29 rush yards in Week 1. Had a TD pass in 4 of his 5 games at home last season. Passed for 313 yards and 2 TD passes in the last meeting. Aims for his 3rd in a row vs. Mia. with 2+ TD passes.
- RB CHRISTIAN MCCAFFREY led the team with 88 scrimmage yards (68 rush, 20 rec.) in Week 1. Finished 2nd with 2,126 scrimmage yards (1,202 rush, 924 rec.) and 3rd with 17 TDs (10 rush, 7 rec.) in 2025. Had 146 scrimmage yards (80 rec., 66 rush) and a TD catch in his last game vs. Mia. (12/4/22).
- WR MIKE EVANS had 6 catches for 49 yards and a TD last week. Ranks 1st with 13,101 rec. yards and 2nd with 108 TD catches since 2014. Had a TD catch in his last game vs. Mia. (12/28/25 w/ TB).
- WR DEMARCUS ROBINSON led the team with 50 rec. yards and had a TD catch in Week 1.
- WR DEEBO SAMUEL recorded 6 catches for 48 yards and a TD catch last week. Aims for his 3rd in a row vs. Mia. with 70+ rec. yards and a TD catch (w/ SF & Was.).
- TE GEORGE KITTLE ranks 2nd with 597 receptions for 8,020 yards and 3rd with 52 TD catches among TEs since 2017. Had 8 catches for 106 yards in the last meeting.
- DL NICK BOSA had 2 TFL in Week 1. Ranks 8th with 64.5 sacks since 2019. Aims for his 3rd in a row vs. Mia. with a TFL.
- LB FRED WARNER led the team with 11 tackles and had a PD and FF in Week 1. Ranks 5th since 2018 with 958 tackles and is tied for 4th with 18 FFs. Had 11 tackles in the last meeting.
- LB DRE GREENLAW had 6 tackles in Week 1.
- CB UPTON STOUT ranked 3rd among rookie DBs in 2025 with 82 tackles.
- CB RENARDO GREEN had an INT last week. Had 10 tackles and a PD in the last meeting. Had a PD in 3 of his last 4 games at home in 2025.
- DB DEOMMODORE LENOIR had 6 tackles in Week 1. Aims for his 3rd in a row vs. Mia. with a PD.
Dolphins Notes
- QB MALIK WILLIS passed for 220 yards and had a rush TD in his Mia. debut. Aims for his 3rd in a row with 220+ pass yards and a rush TD.
- RB DE'VON ACHANE had 66 scrimmage yards (36 rush, 30 rec.) last week. Has 90+ scrimmage yards in 11 of his past 12. Had 190 scrimmage yards (120 rush, 70 rec.), 6 receptions, and a rush TD in the last meeting.
- RB JAYLEN WRIGHT returned 2 kickoffs for 106 yards, including a 79-yard return, the longest in the NFL in Week 1.
- WR CALEB DOUGLAS led rookies in receptions (5) and rec. yards (94) in Week 1.
- WR MALIK WASHINGTON had 53 rec. yards last week.
- TE GREG DULCICH has 30+ rec. yards in 3 of his past 4 games on the road.
- LB JORDYN BROOKS had 9 tackles in Week 1. Aims for his 16th in a row with 5+ tackles. Had 7 tackles and a sack in the last meeting.
- LB JACOB RODRIGUEZ (rookie) led the team with 14 tackles in his NFL debut.
- LB WILLIE GAY had 8 tackles and 0.5 sack in his only regular-season game vs. SF (10/23/22 w/ KC).
- DL ZACH SIELER had 3 tackles and 2 TFL last week. Has a TFL in 6 of his past 7. Aims for his 7th in a row on the road with a TFL and his 4th in a row vs. SF with 0.5+ sacks.
- DL JORDAN PHILLIPS had 4 tackles in Week 1.
- EDGE CHOP ROBINSON had a sack and PD in the last meeting.
- EDGE JOSH UCHE had 4 tackles in his Mia. debut. Had 3 tackles in his only career game vs. SF (9/29/24 w/ NE).
- CB CHRIS JOHNSON (rookie) had 11 tackles, 2 PD, and a TFL in his NFL debut, making him the only rookie with 2+ PD and a TFL in Week 1.
- S ZAYNE ANDERSON had 5 tackles, a TFL, and a PD in his Mia. debut.
- S DANTE TRADER had 3 tackles, a PD, and an INT in Week 1.
- S MICHAEL TAAFFE (rookie) had 4 tackles, a PD, and an INT in his NFL debut.
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