While the 49ers are firmly in the NFC playoff hunt and looking to keep pace in the NFC West, the Browns are desperate for a win to salvage a disappointing season.
The challenge for San Francisco will be navigating Cleveland's elite pass rush, led by the league's sack leader, Myles Garrett, and protecting quarterback Brock Purdy in a hostile environment.
The 49ers are coming off a 20-9 victory over the Carolina Panthers, their second straight win, while the Browns enter Week 13 after beating the Las Vegas Raiders 24-10.
| 49ers | Browns | |
|---|---|---|
| Record | 8-4 (3rd NFCW) | 3-8 (4th AFCN) |
| Points Per Game | 23.4 (15th) | 16.9 (29th) |
| Total Offense (YPG) | 348.6 (10th) | 258.5 (31st) |
| Rushing Offense (YPG) | 99.2 (26th) | 94.9 (28th) |
| Passing Offense (YPG) | 249.4 (3rd) | 163.5 (31st) |
| Avg. Time of Possession | 30:29 (14th) | 29:27 (20th) |
| Points Allowed Per Game | 21.8 (11th) | 22.2 (13th) |
| Total Defense (YPG) | 342.7 (t-22nd) | 273.0 (2nd) |
| Rush Defense (YPG) | 100.9 (10th) | 102.3 (12th) |
| Pass Defense (YPG) | 241.8 (26th) | 170.7 (2nd) |
| Sacks | 13.0 (32nd) | 42.0 (2nd) |
| Interceptions | 5 (t-25th) | 9 (t-9th) |
| Punting Avg. (Gross) | 44.8 (t-26th) | 44.8 (t-26th) |
| Turnover Differential | -6 (t-26th) | +2 (13th) |
49ers by the Numbers
Pass-catching threat
Running back Christian McCaffrey has registered 81 receptions this season, the most in the NFL, proving himself to be a reliable and versatile offensive weapon.
Starting off right
The 49ers offense has scored 38 points on their first possession of games this season, tied for the fifth-most in the NFL (Buf. - 51; Det. - 45; NYG - 45; Phi. - 45; LAR - 38).
Time off the clock
The 49ers offense leads the NFL with 25 drives of 5:00 minutes or more this season, demonstrating their ability to sustain long, clock-killing possessions.
Takeaways
Over the last two weeks (Weeks 11-12), the 49ers defense has registered four interceptions, the second-most in the NFL during that span (LAR - 6). Additionally, the 49ers' defense has forced three takeaways in goal-to-go situations this season, the most in the NFL.
49ers Notes
QB Brock Purdy completed 23 of 32 passes (71.9%) for 193 yards and a touchdown in Week 12. He has 200+ passing yards in three of his four starts this season and has thrown a touchdown pass in every game played. He aims for his third straight road game with a 90+ passer rating. He had a touchdown pass in the last meeting.
RB Christian McCaffrey recorded 142 scrimmage yards (89 rushing, 53 receiving) and a rushing touchdown in Week 12, his 10th game this season with 100+ scrimmage yards — the most in the NFL. He is one of three running backs all-time (Larry Centers and Hall of Famer Marshall Faulk) with 50+ games (50) of 50+ receiving yards. He has a scrimmage touchdown in five of his past six road games and had a receiving touchdown in the last meeting. He ranks first in the NFL with 1,581 scrimmage yards and 81 receptions in 2025.
WR Jauan Jennings had a receiving touchdown in Week 12 and has scored in three of his past four games. He aims for his sixth straight game with 40+ receiving yards.
TE George Kittle led the team with 78 receiving yards last week. He is the fifth tight end in NFL history with 7,500+ receiving yards and 50+ receiving touchdowns in his first nine seasons. He is tied for fifth among tight ends with five receiving touchdowns in 2025 and ranks second among tight ends with 571 receptions and 7,709 receiving yards, and third with 50 receiving touchdowns since 2017.
LB Dee Winters has a tackle for loss in two of his past three games and has a career-high six TFLs this season. He has 5+ tackles in four of his past five games.
LB Tatum Bethune has 10+ tackles in five of his past six games.
DE Clelin Ferrell recorded his second sack of the season in Week 12.
CB Upton Stout (rookie) had six tackles and a pass defensed last week. He aims for his seventh straight road game with 5+ tackles.
CB Deommodore Lenoir had five tackles and an interception in the last meeting.
S Ji'Ayir Brown recorded the first two-interception game of his career in Week 12 and has a pass defensed in three of his past four games.
S Malik Mustapha led the team with seven tackles and a tackle for loss last week. He has 5+ tackles in five of his past six games.
Browns Notes
QB Shedeur Sanders (rookie) passed for 209 yards and a touchdown in his first NFL start in Week 12.
RB Dylan Sampson (rookie) led the team with 82 scrimmage yards (59 receiving, 23 rushing) and had a touchdown catch last week.
RB Quinshon Judkins had 47 rushing yards and two rushing touchdowns in Week 12. He ranks tied for second among rookies with seven touchdowns in 2025 and is one of three rookies (TreVeyon Henderson and Tetairoa McMillan) with multiple games of 2+ touchdowns (two). He aims for his fourth straight game with 45+ scrimmage yards.
WR Jerry Jeudy had 39 receiving yards last week.
WR Isaiah Bond (rookie) had 58 receiving yards in Week 12.
TE Harold Fannin Jr. had four catches for 40 yards last week and ranks second among rookie tight ends with 48 receptions this season.
DE Myles Garrett had three sacks and two forced fumbles in Week 12. He is the only NFL player with three games of 3+ sacks in 2025. He leads the NFL with 18 sacks this season and is the third player since 1982 with 16+ sacks in three or more seasons (J.J. Watt and Hall of Famer Reggie White). He has at least 0.5 sacks in all four of his games at Huntington Bank Field this season.
DT Maliek Collins had 2.5 sacks and his first fumble recovery of the season last week. He aims for his fourth straight game with a tackle for loss. He recorded 33 tackles, five sacks, and two fumble recoveries in 17 games with San Francisco in 2024.
LB Carson Schwesinger had 10 tackles and a tackle for loss in Week 12. He leads all rookies with 89 tackles in 2025 and is one of three rookies (Barrett Carter — four; Demetrius Knight Jr. — three) with three or more games of 10+ tackles. He aims for his third straight game with 10+ tackles.
CB Denzel Ward had two passes defensed and a tackle for loss last week. He has a pass defensed in three of his four games at Huntington Bank Field this season.
CB Tyson Campbell had a season-high nine tackles and two passes defensed in Week 12.