Below are several statistics and notes from Monday's game, which were provided by the 49ers Communications staff.
With The Win...
- The San Francisco 49ers have improved to 11-13 all-time against the Carolina Panthers, including a 5-7 record at home.
- The 49ers have won three consecutive regular-season games against the Panthers.
- San Francisco has improved to 3-0 in primetime games this season [W, 26-23 (OT) at LAR (10/2/25); W, 20-10 vs. Atl. (10/19/25)].
- The Niners have won their 54th game on Monday Night Football, tying the Pittsburgh Steelers for the most wins on MNF in NFL history.
- Head coach Kyle Shanahan improved to 3-1 against Carolina and 12-6 against the NFC South as head coach of the 49ers.
Big-Time Opening Drive
- On the 49ers first offensive possession of the game, the unit registered a 15-play, 72-yd. drive that resulted in a 12-yd. TD pass from QB Brock Purdy to WR Jauan Jennings.
- The unit's 15-play scoring drive marked the first time the 49ers offense has opened the game with a TD drive that was 15-or-more plays since registering an 18-play, 93-yd. TD drive vs. LAR (11/15/21).
49ers Defense
- The 49ers defense held the Panthers to converting on just 1 of their 7 third down atts. (14.3%) on the night.
- It marks the lowest opponent third down conversion percentage the unit has allowed since they held the Miami Dolphins to converting on 0 of their 7 third down atts. (0.0%) vs. Mia. (12/4/22).
RB Christian McCaffrey
- RB Christian McCaffrey registered 24 carries for 89 yds. and 1 TD on the ground to go along with 7 recepts. for 53 yds. through the air. McCaffrey's rushing TD gives him 7 this season and 59 in his career.
- With 7 recepts. on the night, McCaffrey has tallied 81 recepts. this season. His 81 recepts. mark the 5th time in his career that he has registered 75-or-more recepts. in a season, making him the 4th RB in NFL history to record at least 75 recepts. in 5 career seasons, joining former NFL RB Larry Centers, HOF RB Marshall Faulk and New Orleans Saints RB Alvin Kamara.
- On the opening drive of the game, McCaffrey registered 6 carries for 28 yds. and 3 recepts. for 12 yds. His 9 total touches tied his career high for the most touches on the opening drive of a game [9 touches vs. GB (12/17/17) as a member of the Carolina Panthers].
- With 142 yds. from scrimmage, McCaffrey registered his 10th game this season with 100-or-more yds. from scrimmage, which is the most by any player in the NFL. He also registered his 67th career game with 100-or-more yds. from scrimmage and his 30th such game as a member of the 49ers.
- McCaffrey's 67 games with 100-or-more yds. from scrimmage are the most among active NFL RBs.
MOST GAMES WITH 100-OR-MORE YDS. FROM SCRIMMAGE, ACTIVE NFL RBs
| Rank | Player | Games |
| 1. | RB Christian McCaffrey, Car./SF | 67 |
| 2. | RB Derrick Henry, Ten./Bal. | 63 |
| 3. | RB Alvin Kamara, NO | 59 |
| 4. | RB Saquon Barkley, NYG/Phi. | 50 |
| 5. | RB Josh Jacobs, Oak./LV/GB | 42 |
- McCaffrey's 30 games with 100-or-more yds. from scrimmage surpass former RB Garrison Hearst for the 4th-most such games in franchise history.
MOST GAMES WITH 100-OR-MORE YDS. FROM SCRIMMAGE, FRANCHISE HISTORY
| Rank | Player | Games |
| 1. | WR Jerry Rice | 70 |
| 2. | RB Frank Gore | 66 |
| 3. | RB Roger Craig | 50 |
| 4. | RB Christian McCaffrey | 30 |
| 5. | RB Garrison Hearst | 29 |
- With 89 rushing yds. and 53 rec. yds., McCaffrey recorded his 38th career game with 50-or-more rushing yds. and 50-or-more rec. yds., which is the 2nd-most such games in NFL history (RB Marshall Faulk, Ind./StL – 41 games).
MOST GAMES WITH 50-OR-MORE RUSHING YDS. AND 50-OR-MORE REC. YDS., NFL HISTORY
| Rank | Player | Games |
| 1. | RB Marshall Faulk, Ind./StL | 41 |
| 2. | RB Christian McCaffrey, Car./SF | 38 |
| 3. | RB Alvin Kamara, NO | 24 |
| 4t. | RB Tiki Barber, NYG | 23 |
| RB LaDanian Tomlinson, SD/NYJ | 23 |
- Of those 38 games, McCaffrey has recorded 14 as a member of the 49ers. His 14 games with 50-or-more rushing yds. and 50-or-more rec. yds. are tied for the 2nd-most in franchise history.
MOST GAMES WITH 50-OR-MORE RUSH YDS. AND 50-OR-MORE REC. YDS., FRANCHISE HISTORY
| Rank | Player | Games |
| 1. | RB Roger Craig | 17 |
| 2t. | RB Christian McCaffrey | 14 |
| RB Frank Gore | 14 | |
| 4. | RB Ricky Watters | 8 |
| 5. | RB Charlie Garner | 7 |
- McCaffrey's 53 rec yds. mark his 50th career game with 50-or-more rec. yds., which is tied for the 2nd-most games with at least 50 rec. yds. by a RB in the Super Bowl Era.
MOST GAMES WITH 50-OR-MORE REC. YDS. BY A RB, SUPER BOWL ERA
| Rank | Player | Games |
| 1. | RB Larry Centers, Pho./Arz./Was./Buf./NE | 55 |
| 2t. | RB Christian McCaffrey, Car./SF | 50 |
| RB Marshall Faulk, Ind./StL | 50 | |
| 4. | RB Ronnie Harmon, Buf./SD/Hou. | 47 |
| 5. | RB Keith Byars, Phi./Mia./NE/NYJ | 46 |
WR Jauan Jennings
- WR Jauan Jennings tallied 5 recepts. for 41 yds. and 1 TD on the day. His TD recept. marked his 4th of the season and the 17th of his career.
S Ji'Ayir Brown
- S Ji'Ayir Brown notched5 tackles and 2 INTs of Panthers QB Bryce Young on the night, marking his first INTs of the season and giving him 5 in his career.
- Brown's INTs of Young marked his first since he registered 1 INT vs. Dal. (10/27/24).
- With 2 INTs on the night, Brown became the first 49ers player to register 2-or-more INTs in a single game since former CB Charvarius Ward in 2023 [2 INTs at Arz. (12/17/23)].
DL Clelin Ferrell
- DL Clelin Ferrell notched 1 tackle and 1 sack of Young on the night. His sack gives him 2.0 on the season and 19.0 in his career.
LB Nick Martin
- LB Nick Martin tallied 2 tackles on special teams and registered 1 special teams FF, marking the first special teams FF of his career.
K Matt Gay
- K Matt Gay converted on each of his FGAs (47 & 29) and both of his PATs in his debut with the team.