Below are several statistics and notes from Sunday's game, which were provided by the 49ers Communications staff.
With The Win...
- The San Francisco 49ers have improved 38-31 all-time against the Arizona Cardinals, including a 17-16 record on the road.
- The 49ers have won seven of the last 11 matchups against the Cardinals.
- The Niners have won three of the last four games against the Cardinals at State Farm Stadium.
- The 49ers have swept the regular season series against the Cardinals for the 11th time since 2002 and for the first time since the 2023 season.
- The Niners have won each of their 3 NFC West road games this season, marking the 4th time since 2002 that the team has won each of their road games against NFC West opponents (2019, 2022 & 2023).
- Head coach Kyle Shanahan improved to 9-9 against the Cardinals and 28-25 against the NFC West as head coach of the 49ers.
41 in the Desert
- The 49ers scored 25 points in the first half of today's game, marking the most points that the team has scored in the first half of a game since scoring 28 first half points vs. TB (12/11/22).
- The Niners finished the day with 41 total points scored, marking the most points the team has scored in a single game since scoring 45 points at Arz. (12/17/23).
49ers Defense
- The 49ers defense held the Cardinals to 36 total rushing yds. on the day, marking the fewest opponent rushing yds. the team has allowed since holding the New York Giants to 29 rushing yds. [vs. NYG (9/21/23)].
- The Niners defense also forced 3 takeaways on the day (2 INTs, 1 FF), marking the first time the unit has forced 3 takeaways in a single game since recording 2 INTs and 1 FF at Sea. (10/10/24).
Purdy-Kittle Connection
- QB Brock Purdy connected with TE George Kittle for 2 TDs on the day, marking the 23rd TD pass that Purdy has thrown to Kittle.
- The duo's 23 TDs are the 2nd-most by a 49ers QB/TE duo in franchise history.
MOST TDs FOR A QB/TE DUO, FRANCHISE HISTORY
| Rank | Players | TDs |
| 1. | Alex Smith and Vernon Davis | 30 |
| 2. | Brock Purdy and George Kittle | 23 |
| 3. | Steve Young and Brent Jones | 22 |
QB Brock Purdy
- QB Brock Purdy completed 19 of his 26 passing atts. for 200 yds. and a season-high 3 TDs with a season-high passer rating of 133.5 on the day. Purdy's 3 passing TDs give him 7 on the season and 71in his career.
- With 3 passing TDs on the day, Purdy recorded his 10th career game with 3-or-more passing TDs and his first such game since he threw 3 passing TDs vs. Det. (12/30/24). He also registered 3 passing TDs and zero INTs for the 9th time in his career and for the first time since 2024 [3 passing TDs and zero INTs at Sea. (10/10/24)].
- Purdy also registered his 8th career game with at least 3 passing TDs and a passer rating of 130.0 or higher. Today's game marked the first time he's accomplished the feat since throwing for 3 passing TDs with a passer rating of 137.1 at LAR (9/22/24).
- With a passer rating of 133.5, Purdy registered his 11th career game with a passer rating of at least 130.0. His 11 games with a passer rating of 130.0-or-higher are the most by any QB in their first 4 seasons since at least 1970.
RB Christian McCaffrey
- RB Christian McCaffrey registered 13 carries for 81 yds. and 2 TDs on the ground to go along with 5 recepts. for 40 yds. and 1 TD through the air.
- McCaffrey's 2 rushing TD gives him 6 this season and 58 in his career, while his TD recept. gives him 5 this season and 34 in his career. With 6 rushing TDs and 5 rec. TDs this season, McCaffrey has registered his 4th career season with at least 5 rushing TDs and 5 rec. TDs, making him the first player in NFL history to accomplish the feat.
- With 2 rushing TDs and 1 TD recept. on the day, McCaffrey recorded his 17th career game with 1 or more rushing TD and 1-or-more TD recept., extending his record for the most games in a career with at least 1 rushing TD and 1 TD recept. in NFL history.
- It also marks McCaffrey's 8th game with 1-or-more rushing TD and 1-or-more TD recept. as a member of the 49ers, the most such games in franchise history.
- McCaffrey's 34 career TD recepts. are the 2nd-most by a RB in the Super Bowl Era.
MOST TD RECEPTS. BY A RB, SUPER BOWL ERA
| Rank | Player | TD Recepts. |
| 1. | RB Marshall Faulk, StL/Ind. | 36 |
| 2. | RB Christian McCaffrey, Car./SF | 34 |
| 3. | RB Darren Sproles, SD/NO/Phi. | 32 |
| 4t. | RB James Brooks, SD/Cin./Cle./TB | 30 |
| RB Austin Ekeler, LAC/Was. | 30 | |
| RB Brian Westbrook, Phi./SF | 30 |
- With 121 yds. from scrimmage, McCaffrey registered his 9th game this season with 100-or-more yds. from scrimmage, which is the most by any player in the NFL. He also registered his 66th career game with 100-or-more yds. from scrimmage and his 29th such game as a member of the 49ers.
- McCaffrey's 66 games with 100-or-more yds. from scrimmage are the most among active NFL RBs.
MOST GAMES WITH 100-OR-MORE YDS. FROM SCRIMMAGE, ACTIVE NFL RBs
| Rank | Player | Games |
| 1. | RB Christian McCaffrey, Car./SF | 66 |
| 2. | RB Derrick Henry, Ten./Bal. | 63 |
| 3. | RB Alvin Kamara, NO | 59 |
| 4. | RB Saquon Barkley, NYG/Phi. | 50 |
| 5. | RB Josh Jacobs, Oak./LV/GB | 42 |
- McCaffrey's 29 games with 100-or-more yds. from scrimmage are tied for the 4th-most in franchise history.
MOST GAMES WITH 100-OR-MORE YDS. FROM SCRIMMAGE, FRANCHISE HISTORY
| Rank | Player | Games |
| 1. | WR Jerry Rice | 70 |
| 2. | RB Frank Gore | 66 |
| 3. | RB Roger Craig | 50 |
| 4t. | RB Christian McCaffrey | 29 |
| RB Garrison Hearst | 29 |
TE George Kittle
- TE George Kittle caught all 6 of his targets for 67 yds. and 2 TDs on the day. His TD recepts. marked his 5th of the season and gave him 50 in his career.
- Kittle's 2 TD recepts. on the day give him 50 TD recepts. in his career, which is the 5th-most TD recepts. by any player in franchise history.
MOST TD RECEPTS., FRANCHISE HISTORY
| Rank | Player | TD Recepts. |
| 1. | WR Jerry Rice | 176 |
| 2. | WR Terrell Owens | 81 |
| 3. | WR Gene Washington | 59 |
| 4. | TE Vernon Davis | 55 |
| 5. | TE George Kittle | 50 |
- Kittle's 6 recepts. and 2 TDs on the day give him 565 recepts. and 50 TDs in his career, making him the 3rd player in franchise history to record 500-or-more recepts. and 50-or-more TDs in a career (HOF WR Terrell Owens – 592 recepts. & 81 TDs; HOF WR Jerry Rice – 1,281 recepts. & 176 TDs).
- With 2 TD recepts. on the day, Kittle registered his 8th career game with 2 or more TD recepts. and his first such game since he recorded 2 TD recepts. at Sea. (10/10/24).
- With 1 TD recept. last week vs. LAR (11/9/25) and 2 TD recepts. on the day, Kittle has recorded 1 or more TD recepts. in back-to-back games for the 12th time in his career and for the first time since the 2024 season [1 TD recept. vs. Dal. (10/27/24); 1 TD recept. at TB (11/10/24)].
S Malik Mustapha
- S Malik Mustapha tallied 4 tackles and 1 INT of Cardinals QB Jacoby Brissett on the day. His INT marked his first of the season and the 2nd of his career.
DB Deommodore Lenoir
- DB Deommodore Lenoir notched 7 tackles and 1 INT of Brissett, which he returned for 64 yds. His INT marked his 2nd of the season and the 8th of his career.
- Lenoir's 64-yd. INT return marked the longest INT return by a 49ers player since former CB Charvarius Ward returned an INT 66 yds. for a TD at Arz. (12/17/23).
DB Upton Stout
- DB Upton Stout tallied 7 tackles and 1 FF on the day, which was recovered by DL Keion White, who added 1 tackle.
- Stout's FF marked the first of his career, while White's FR also marked the first of his career.
WR Skyy Moore
- WR Skyy Moore registered a 98-yd. kickoff return on the opening kickoff of the game.
- Moore's 98-yd. return marked the longest kickoff return by a 49ers player since former WR Ted Ginn Jr. registered a 102-yd. kickoff return for a TD vs. Sea. (9/11/11).
K Eddy Piñeiro
- K Eddy Piñeiro converted on each of his 3 FGAs (48, 47, 47) on the day.
- With 3 consecutive FGM, Piñeiro has converted on each of his first 22 FGAs since joining the team in Week 2, continuing his streak for the most FGM by any kicker to begin their first season with the 49ers.
- With 22 consecutive FGM, Piñeiro also surpassed former K Phil Dawson for the 4th-most consecutive FGM in franchise history.
MOST CONSECUTIVE FGM, FRANCHISE HISTORY
| Rank | Player | Dates | Consecutive FGM |
| 1. | K Robbie Gould | 10/29/17 – 10/7/18 | 33 |
| 2. | K Phil Dawson | 10/6/13 – 12/29/13 | 27 |
| 3. | K Robbie Gould | 10/15/18 – 9/8/19 | 25 |
| 4. | K Eddy Piñeiro | 9/14/25 – Present | 22 |
| 5. | K Phil Dawson | 9/14/15 – 12/13/15 | 19 |