Previous game
The 49ers are coming off a 20-10 victory over the Atlanta Falcons. The offense posted a season-high 174 rushing yards, led by RB Christian McCaffrey, who carried the ball 24 times for 129 yards and scored a season-high two rushing touchdowns, in addition to catching seven passes for 72 yards.
Defensively, San Francisco sacked Falcons QB Michael Penix Jr. twice and held Atlanta to just 62 rushing yards. LB Tatum Bethune tied his career high with 10 tackles, while DL Bryce Huff recorded five tackles, 1.0 sack, and a forced fumble. DL Sam Okuayinonu contributed three tackles and a sack of Penix Jr., helping anchor the defensive effort.
Below is everything you need to know to follow the upcoming game.
When does the game start?
Sunday, October 26 at 10:00 a.m. PT
Where is the game being played?
NRG Stadium in Houston, Texas
Who are the head coaches?
49ers: Kyle Shanahan
Texans: DeMeco Ryans
Betting Odds
As of October 22, the Texans are favored by 1.5 points in this game, with an over/under set at 41.5 points, per BetMGM.
What channel is the game on?
Network: FOX
Play-By-Play: Kevin Kugler
Color Analyst: Daryl Johnston
Sideline Reporter: Allison Williams
Viewers outside the broadcast area can watch the game via NFL Sunday Ticket on YouTube TV or YouTube Premium, but a subscription to the package is required.
What areas will receive the broadcast?
The broadcast will be viewable within the markets designated below for those without NFL Sunday Ticket.
Coverage map courtesy of 506sports.com
Where can I stream the game?
NFL Sunday Ticket subscribers can stream the game using the YouTube TV app. Those who purchased through YouTube Premium can watch via the YouTube app. Additionally, NFL+ subscribers can stream the game in its entirety once the matchup has been completed.
Bay Area fans can stream the game through the official 49ers app or at 49ers.com.
Where can I listen to the radio broadcast?
49ers Radio
Bay Area fans can listen on KGO 810 AM and The Bone 107.7 FM, where Guy Haberman and Tim Ryan will call the game.
Jesús Zárate and Carlos Yustis will call the game in Spanish. Fans can listen at 49ers.com/esp.
Texans Radio
Houston area fans can listen on Sports Radio 610 and The Bull 100.3 FM, where Marc Vandermeer and Andre Ware will call the game.
National Radio
Fans can listen to the game via Sports USA Radio, where Bob Fitzgerald and Marvin Lewis will provide the call.
Streaming
NFL+ subscribers can listen to the game through that service.
Game discussion
Fans can discuss the game within our Niner Talk forum.
How has this series played out historically?
Matchups: 5
Series Record: 49ers lead series 4-1
49ers Home Record vs. Texans: 49ers lead series 3-0
49ers Away Record vs. Texans: Series is tied 1-1
First Meeting: 1/1/06, 49ers win 20-17 (OT), at SF
Last Meeting: 1/2/22, 49ers win 23-7, at SF
Current Streak: Won 3
Longest 49ers Win Streak: 3 (10/6/13 - current)
Longest Texans Win Streak: 1 (10/25/09)
Most 49ers Points: 34 (10/6/13): 49ers win 34-3, at SF
Most Texans Points: 24 (10/25/09): Texans win 24-21, at Hou.
49ers Shutouts: None
Texans Shutouts: None
49ers Notes
- QB Brock Purdy has 2+ touchdown passes in each of his past four starts. He has 36 total touchdowns (35 passing, 1 rushing) and a 109.1 passer rating in 18 career road starts.
- QB Mac Jones leads the NFL with 280.8 passing yards per game (minimum five starts) in 2025. He has 275+ passing yards in each of his three road starts this season and aims for his third straight road game with 340+ passing yards. Jones had two touchdowns, zero interceptions, and a 105.6 rating in his last game vs. Houston (12/1/24 with Jacksonville).
- RB Christian McCaffrey had seven receptions, 201 scrimmage yards (129 rushing, 72 receiving), and two rushing touchdowns in Week 7—his fourth career game with 200+ scrimmage yards. He leads the NFL in scrimmage yards (981) and ranks third in receptions (53) in 2025. McCaffrey is the fifth running back ever with 50+ catches and 500+ receiving yards in six career seasons. He can record his third career streak of five or more catches in eight straight games and join Herschel Walker as the only running backs ever with 50+ receiving yards in eight straight games. He has 47 career games with 50+ receiving yards, tied for the third-most by a running back in the Super Bowl era. McCaffrey aims for his eighth straight game with 100+ scrimmage yards.
- TE George Kittle needs eight receptions to reach 550 and 95 receiving yards to reach 7,500 for his career.
- WR Kendrick Bourne has 5+ catches and 140+ receiving yards in each of his past two road games.
- LB Tatum Bethune led the team with 10 tackles and recorded his first career tackle for loss last week. He aims for his third straight game with 10+ tackles.
- LB Dee Winters recorded his fourth tackle for loss of the season last week.
- DL Sam Okuayinonu recorded his first sack of the season in Week 7.
- DL Alfred Collins (rookie) recovered his second career fumble last week.
- CB Deommodore Lenoir has a pass defended in two of his past three games.
- CB Renardo Green aims for his 11th straight road game with a pass defended.
- S Malik Mustapha recorded six tackles last week.
- S Ji'Ayir Brown had a season-high five tackles in Week 7.
Texans Notes
- QB C.J. Stroud has three touchdown passes and zero interceptions with a 112.7 passer rating in two home starts in 2025. He aims for his third straight home game with a 95+ rating and has thrown a touchdown pass in 18 of his first 19 career home starts.
- RB Nick Chubb has 60+ scrimmage yards in two of his past three games and aims for his third straight home game in 2025 with 60+ scrimmage yards.
- RB Woody Marks (rookie) recorded his second career touchdown reception last week.
- WR Nico Collins has 50+ receiving yards in eight of his past nine home games and aims for his fourth straight at home with 50+ receiving yards. He has seven receiving touchdowns in his past eight home games and needs six catches to reach 250 for his career.
- WR Jaylin Noel (rookie) posted a career-high 77 receiving yards in Week 7.
- TE Dalton Schultz led the team with season highs in receptions (9) and receiving yards (98) in Week 7. He aims for his fifth straight game with 5+ catches and had a touchdown catch in his only career game vs. San Francisco (12/20/20 with Dallas).
- DE Will Anderson recorded his fourth sack of the season, a forced fumble, and his first career fumble-return touchdown last week. He has 33 tackles for loss in 35 career games and 5.5 sacks in his past six home games.
- DE Danielle Hunter has two sacks in both of his home games this season and has 12 sacks and 15 tackles for loss in 10 home games with Houston since 2024. He aims for his third straight game vs. San Francisco with a sack.
- DE Denico Autry recorded a sack in his season debut last week.
- LB Azeez Al-Shaair aims for his fourth straight game with a pass defended. He recorded 191 tackles, 11 tackles for loss, and eight passes defended in 56 games (2019–2022) with San Francisco.
- CB Derek Stingley Jr. had an interception last week and has picks in two of his past three games, along with a pass defended in four of his past five. He has 22 passes defended and nine interceptions in 20 career home games.
- CB Kamari Lassiter set career highs with 10 tackles and three tackles for loss last week. He aims for his fourth straight game with a pass defended.
- S Jalen Pitre recorded a season-high nine tackles last week.
- S Calen Bullock recorded his first interception of the season in Week 7.
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