Watch the play here:
The Jaguars defeated the 49ers 26-21, handing San Francisco its only loss of the season. Since then, the 49ers bounced back with an overtime win over the Los Angeles Rams, improving their record to 4-1 and sitting atop the NFC West.
Through five games, McCaffrey has totaled 669 scrimmage yards and three touchdowns. Still, the All-Pro running back is searching for his first rushing touchdown of the 2025 season.
Related News
More San Francisco 49ers News
-
49ers buzz: NFL insider predicts strong trade market for QB Mac Jones
Several quarterback-needy NFL teams could come calling this offseason to gauge what it might take to acquire San Francisco 49ers quarterback Mac Jones. Pressed into action as Brock Purdy's backup, Jones made the most of his opportunity in 2025. In eight starts, the former... -
49ers Notebook: Dee Winters recaps his pick six; Two rookies notch first NFL sacks; Jauan Jennings the troll
Things didn't start out too well for the 49ers defense in their 48-27 win over the Indianapolis Colts on Monday night, but by the time the game was over, there were a few memorable highlights for multiple players on that side of the ball. Leading the way in that regard was... -
49ers' Trent Williams on NFL future: 'I'm nowhere near done'
San Francisco 49ers left tackle Trent Williams is not contemplating retirement anytime soon. Despite being 37 years old, Williams continues to perform at an elite level and believes he still has plenty of football left in him. Williams has earned a Pro Football Focus grade... -
49ers bolster interior O-line in 2026 NFL mock draft
CBS Sports analyst Mike Renner released his latest 2026 NFL mock draft, projecting the San Francisco 49ers to address a clear roster need: the interior offensive line. While many expected the 49ers to invest early in the offensive line during the 2025 NFL Draft, the unit...