Previous game
San Francisco is coming off a 26-21 loss to the Jacksonville Jaguars. On offense, quarterback Brock Purdy completed 22 of 38 passes for a season-high 309 yards and two touchdowns. Tight end Jake Tonges hauled in three receptions for a career-high 58 yards and a touchdown, while running back Christian McCaffrey posted six receptions for a team-high 92 yards and a score, adding 49 rushing yards on 17 carries.
Defensively, the 49ers limited Jacksonville to 174 passing yards. Linebacker Dee Winters led the way with a career-high 10 tackles and one pass defensed. Fellow linebacker Fred Warner added eight tackles and a forced fumble, while safety Marques Sigle recorded a career-high eight tackles along with the first pass defensed of his career.
Below is everything you need to know to follow the upcoming game.
When does the game start?
Thursday, October 2 at 5:15 p.m. PT
Where is the game being played?
SoFi Stadium in Inglewood, California
Who are the head coaches?
49ers: Kyle Shanahan
Rams: Sean McVay
Betting Odds
As of September 30, the Rams are favored by 6.5 points in this game, with an over/under set at 46.5 points, per BetMGM.
What channel is the game on?
Network: Amazon Prime Video
Play-By-Play: Al Michaels
Color Analyst: Kirk Herbstreit
Sideline Reporter: Kaylee Hartung
What areas will receive the broadcast?
The game is available to anyone with access to Amazon Prime Video online streaming.
Bay Area fans can watch the broadcast on KTVU FOX 2. Los Angeles area fans can watch on KTTV FOX 11.
Where can I listen to the radio broadcast?
49ers Radio
Bay Area fans can listen on KGO 810 AM and The Bone 107.7 FM, where Guy Haberman and Tim Ryan will call the game.
Jesús Zárate and Carlos Yustis will call the game in Spanish. Fans can listen at 49ers.com/esp.
Rams Radio
Los Angeles area fans can listen on ESPN 710 AM, where J.B. Long and Maurice Jones-Drew will call the game.
National Radio
Fans can listen to the game via Westwood One Sports, where Kevin Kugler and Ross Tucker will provide the call.
Streaming
NFL+ subscribers can listen to the game through that service.
Game discussion
Fans can discuss the game within our Niner Talk forum.
How has this series played out historically?
Matchups: 152
Series Record: 49ers lead series 78-71-3
49ers Home Record vs. Rams: 49ers lead series 38-36-2
49ers Away Record vs. Rams: 49ers lead series 40-35-1
First Meeting: 10/1/50, Rams win 35-14, at SF
Last Meeting: 12/12/24, Rams win 12-6, at SF
Current Streak: Lost 3
Longest 49ers Win Streak: 17 (12/17/90 – 12/27/98)
Longest Rams Win Streak: 10 (11/29/70 – 9/28/75)
Most 49ers Points: 48 (12/27/87): 49ers win 48-0, at SF
Most Rams Points: 56 (11/9/58): Rams win 56-7, at LA
49ers Shutouts: 9 (Last 9/12/16), 49ers win 28-0, at SF
Rams Shutouts: None
49ers Notes
- QB Brock Purdy passed for 309 yards and 2 TDs last week, marking his 11th career 300-yard game—the 2nd-most in the NFL since 2023. Aims for his 5th straight game with 275+ pass yards and 2+ TDs. Threw for 292 yards and 3 TDs with 0 INTs (137.1 rating) in his last road meeting (9/22/24).
- RB Christian McCaffrey had 6 receptions, 141 scrimmage yards (92 receiving, 49 rushing), and his 31st career receiving TD last week. One of 3 RBs (James Cook, Bijan Robinson) with 100+ scrimmage yards in each of the first 4 weeks. Ranks 3rd in the NFL in scrimmage yards (530) and receptions (31). Has 28 receptions (7 per game), 651 scrimmage yards (162.8 per game), and 5 TDs (4 rush, 1 rec.) in 4 career games vs. LAR, including 135+ scrimmage yards in each. Aims for his 4th straight Thursday game with 115+ scrimmage yards and a rushing TD.
- WR Ricky Pearsall ranks 4th in the NFL with 327 receiving yards in 2025 and has 50+ receiving yards in 5 of his past 6 games. Aims for his 8th straight game with 4+ catches.
- WR Jauan Jennings has 50+ receiving yards in 4 of his past 5 road games. Set career highs in catches (11), yards (175), and TDs (3) in his last road meeting (9/22/24).
- TE Jake Tonges recorded a career-high 58 receiving yards and his 2nd career TD catch last week.
- LB Fred Warner had 8 tackles and his 17th career forced fumble last week. Tallied 15 tackles in the last meeting and has a pass defensed in 4 of his past 5 vs. LAR. Has 79 tackles (8.8 per game) in 9 career Thursday games.
- LB Dee Winters led the team with a career-high 10 tackles, adding a TFL and pass defensed in Week 4. Aims for his 3rd straight game with a pass defensed.
- DL Bryce Huff has a sack in 2 of his past 3 games and aims for his 4th straight game with a TFL.
- CB Deommodore Lenoir aims for his 4th straight game with a TFL. Had 2 passes defensed in the last meeting.
- S Marques Sigle posted a career-best 8 tackles and his 1st career pass defensed last week. Only rookie DB with 5+ tackles in each of the first 4 weeks.
Rams Notes
- QB Matthew Stafford passed for 375 yards and 3 TDs with 0 INTs (123.5 rating) last week, his 18th career game with 375+ passing yards. Aims for his 4th straight game with 2+ TD passes. Has won 4 of his past 5 Thursday starts.
- RB Kyren Williams totaled 94 scrimmage yards (77 rushing, 17 receiving) last week and has 50+ scrimmage yards in 32 straight games, the longest active streak in the NFL. Has 12 TDs (10 rush, 2 rec.) in his past 10 home games. Has 328 scrimmage yards (109.3 per game) and 5 TDs (3 rush, 2 rec.) in 3 career games vs. SF, including 3 TDs (2 rush, 1 rec.) in his last home meeting (9/22/24). Aims for his 4th straight Thursday game with 100+ scrimmage yards.
- WR Puka Nacua had 13 receptions for a career-high 170 yards and his 10th career TD catch last week, his 7th career game with 10+ catches and 100+ receiving yards. Became the 2nd player ever (joining Cooper Kupp, 2022) with 10+ catches and 100+ receiving yards in 3 of his team's first 4 games of a season. Leads the NFL with 42 receptions, tied for the most by any player through a team's first 4 games in league history. Had a career-high 15 receptions for 147 yards in his only career home game vs. SF (9/17/23).
- WR Davante Adams aims for his 4th straight game with a receiving TD and 5th straight with 50+ receiving yards. Has 106 career regular-season TD catches, tied with Mike Evans for most among active players and tied for 9th-most in NFL history. Has 46 receptions (9.2 per game) for 633 yards (126.6 per game) and 7 TDs in 5 career games vs. SF—scoring in every game and posting 7+ receptions and 130+ yards in 4 of 5.
- LB Byron Young is 1 of 2 players (with Brian Burns) with a sack in each of the first 4 weeks. Has a sack in 3 of his 4 career games vs. SF and aims for his 4th straight vs. the 49ers with a TFL.
- LB Jared Verse aims for his 3rd straight game with a sack and forced fumble.
- DE Kobie Turner recorded 2 sacks in the last meeting.
- S Kam Curl posted a career-high 3 passes defensed and his 1st career multi-INT game last week. Aims for his 7th straight game with 5+ tackles. Had 2 PD in the last meeting.
- S Quentin Lake had 2 passes defensed in the last meeting. Aims for his 4th straight game with 5+ tackles.