Below are several statistics and notes from Sunday's game, which were provided by the 49ers Communications staff.
With The Win...
- San Francisco has started the regular season 3-0 for the 10th time in franchise history and for the third time since 2019 (2019 & 2023).
- The Niners have won six of the previous 10 matchups against the Cardinals, including three of the last five matchups at Levi's Stadium.
- The 49ers are now 37-31 all-time against the Cardinals, including a 21-15 record at home.
Dramatic Finish
- The 49ers defeated the Cardinals 16-15 after a 35-yd. FGA by K Eddy Piñeiro as time expired. It marked the first time that the 49ers won a game after trailing with less than 10 seconds left in regulation since former K Robbie Gould converted on a 30-yd. FGA as time expired at NO (12/8/19).
Time of Possession
- San Francisco held the ball for 25:21, compared to Arizona's 34:39. It marked the first time since 12/17/23 at Arz. (25:49-34:11) that the 49ers won despite having the ball for less time than their opponent.
QB Mac Jones
- QB Mac Jones completed 27 of his 41 passing atts. for 284 yds. and 1 TD with a passer rating 83.8. His passing TD marked his 4th of the season and the 58th of his career.
- With 279 passing yds. last week at NO (9/14/25) and 284 passing yds. on the day, it marks the 3rd time in Jones' career that he has thrown for 250-or-more yds. in back-to-back games and the first time he has done so since the 2022 season when he was a member of the New England Patriots [252 passing yds. at Pit. (9/18/22); 321 passing yds. vs. Bal. (9/25/22)].
RB Christian McCaffrey
- RB Christian McCaffrey registered 17 carries for 52 yds. on the ground to go along with 10 recepts. for 88 yds. through the air.
- His 88 rec. yds. mark the most he has registered as a member of the 49ers and the most in a single game since he tallied 89 rec. yds. in Week 6 of the 2022 season as a member of the Carolina Panthers [89 rec. yds. at LAR (10/16/22)].
- With 140 yds. from scrimmage, McCaffrey registered his 60th career game with 100-or-more yds. from scrimmage and his 23rd such game as a member of the 49ers.
- With 69 rushing yds. and 73 rec. yds. Week 1 at Sea. (9/7/25), 55 rushing yds. and 52 rec. yds. Week 2 at NO (9/14/25) and 52 rushing yds. and 88 rec. yds. on the day, McCaffrey became the first 49ers player since at least 1950 to register 50-or-more rushing yds. and 50-or-more rec. yds. in each of the first 3 weeks of the season. He also became the first NFL player to accomplish the feat since HOF RB Marshall Faulk in 2000.
- McCaffrey's 60 games with 100-or-more yds. from scrimmage are tied for the most among active NFL RBs.
MOST GAMES WITH 100-OR-MORE YDS. FROM SCRIMMAGE, ACTIVE NFL RBs
| Rank | Player | Games |
| 1t. | RB Christian McCaffrey, Car./SF | 60 |
| RB Derrick Henry, Ten./Bal. | 60 | |
| 3. | RB Alvin Kamara, NO | 58 |
| 4. | RB Saquon Barkley, NYG/Phi. | 48 |
| 5t. | RB Nick Chubb, Cle./Hou. | 39 |
| RB Joe Mixon, Cin./Hou. | 39 |
- With 142 yds. from scrimmage Week 1 at Sea. (9/7/25), 107 yds. from scrimmage Week 2 at NO (9/14/25) and 140 yds. from scrimmage on the day, McCaffrey became the first 49ers player to register 100-or-more yds. from scrimmage in each of the first 3 weeks of the season since he accomplished the feat in 2023 [169 yds. from scrimmage Week 1 at Pit. (9/10/23); 135 yds. from scrimmage Week 2 at LAR (9/17/23); 119 yds. from scrimmage Week 3 vs. NYG (9/21/23)].
- With 52 rushing yds. and 88 rec. yds., McCaffrey registered his 33rd career game with 50-or-more rushing yds. and 50-or-more rec. yds., which is the 2nd-most such games in NFL history (RB Marshall Faulk, Ind./StL – 41 games).
MOST GAMES WITH 50-OR-MORE RUSHING YDS. AND 50-OR-MORE REC. YDS., NFL HISTORY
| Rank | Player | Games |
| 1. | RB Marshall Faulk, Ind./StL | 41 |
| 2. | RB Christian McCaffrey, Car./SF | 33 |
| 3. | RB Alvin Kamara, NO | 24 |
| 4t. | RB Tiki Barber, NYG | 23 |
| RB LaDanian Tomlinson, SD/NYJ | 23 |
- Of those 33 games, McCaffrey has recorded 9 as a member of the 49ers. His 9 games with 50-or-more rushing yds. and 50-or-more rec. yds. are the 3rd-most in franchise history.
MOST GAMES WITH 50-OR-MORE RUSH YDS. AND 50-OR-MORE REC. YDS., FRANCHISE HISTORY
| Rank | Player | Games |
| 1. | RB Roger Craig | 17 |
| 2. | RB Frank Gore | 14 |
| 3. | RB Christian McCaffrey | 9 |
| 4. | RB Ricky Watters | 8 |
| 5. | RB Charlie Garner | 7 |
FB Kyle Juszczyk
- FB Kyle Juszczyk recorded a 1-yd. TD recept. on the day, marking his first of the season and the 19th of his career.
WR Ricky Pearsall
- WR Ricky Pearsall notched 8 recepts. for a team-high 117 yds., marking his 2nd game of the season with 100-or-more rec. yds. and the 3rd such game of his career.
DL Bryce Huff
- DL Bryce Huff registered 5 tackles, 1 PD and 1.0 sack of Cardinals QB Kyler Murray. His PD marked his first of the season and the 4th of his career, while his sack of Murray marked his 2nd of the season and gives him 22.0 in his career.
- With 1.0 sack last week at NO and 1.0 sack on the day, it marked the 6th time in Huff's career that he has registered 1.0-or-more sack in back-to-back games and the first time he has done so since the 2023 season as a member of the New York Jets [1.0 sack vs. Hou. (12/10/23); 1.0 sack at Mia. (12/17/23)].
LB Fred Warner
- LB Fred Warner registered a team-high 11 tackles and 2 PDs on the day.
- Warner's 2 PDs give him 3 on the season and 56 in his career, extending his record for most PDs by a LB in franchise history (PDs became an official statistic in 1994).
DL Nick Bosa
- DL Nick Bosa registered 2 tackles and 1 FF on the day. With 1 FF, Bosa recorded his 2nd FF of the season and the 13th of his career, which is tied for the 3rd-most by a 49ers player since FFs became an official statistic in 1994.
MOST FORCED FUMBLES BY A 49ERS PLAYER, SINCE 1994
| Rank | Player | FFs |
| 1t. | LB Fred Warner | 16 |
| LB Patrick Willis | 16 | |
| 3t. | DL Nick Bosa | 13 |
| DL Roy Barker | 13 | |
| 5t. | LB Ahmad Brooks | 11 |
| DL Chris Doleman | 11 | |
| DL Bryant Young | 11 |
K Eddy Piñeiro
- K Eddy Piñeiro converted on each of his 3 FGAs (38, 51, 35) and his lone PAT on the day.
- Piñeiro's 35-yd. FGM as time expired marked the first time that a 49ers kicker converted on a game-winning FGA since former K Jake Moody connected on a 44-yd. FGA as time expired at TB (11/10/24).
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