Stop the Run
Expect the Cardinals to set the tone by establishing their run game. James Connor and Trey Benson will look to establish a ground-and-pound approach for the Cardinals. The 49ers' defensive front cannot allow the Cardinals' run game to break through for explosive plays. They gave up 121 yards to Alvin Kamara and the Saints last week.
Sunday will be Robert Saleh's first actual test against a mobile quarterback this season. Kyler Murray could be the X factor for the Cardinals' run game. The 49ers defense cannot forget the running ability of Murray. They must contain on the outside and keep someone over the middle if he decides to take off and run. If the 49ers' defense can stop the run, they will have a good chance of winning the game.
Limit Trey McBride
Trey McBride was the leading pass catcher for the Cardinals in 2024, and he continues to get high target volume in 2025. The 49ers' safeties struggled against Juwan Johnson of the New Orleans Saints in Week 2, giving up a touchdown.
Even if the defense allows McBride to create explosive plays, they must find a way to keep him out of the end zone. Whoever is responsible for McBride—whether it's Fred Warner, Dee Winters, Marques Sigle, Jason Pinnock, or Ji'Ayir Brown—must do a good job of limiting McBride's production.
Attack The Secondary
The Cardinals' secondary has been hit with the injury bug. They're also young and ranked 26th in passing, allowing 255.5 yards per game. Expect Brock Purdy or Mac Jones to push the ball down the field for explosive plays. This could be the first 49ers game with 300 passing yards. If they can execute down the field, they will be at the top of the NFC West, sitting at 3-0.
Sunday will not be a cakewalk game. This game gives early bragging rights in the NFC West. After being swept in 2024, there's no way the 49ers want to start 2025 by allowing the Cardinals to win three straight. If the 49ers stick to these keys to victory, they will snap the losing streak against Arizona and remain undefeated this season.
Written By:
Wayne Breezie is a 49ers content creator. He had his first guest appearance on Ronbosports in 2012. He began writing for a Facebook group called the League of the 49ers. Next, he began writing for Nothing But Niners in 2017. In 2018, Wayne Breezie made his debut on YouTube’s Nothing But Niners show. In 2019, he started his podcast called Nitty Gritty Niners. After putting the pen down for several years, Breezie saw an opportunity to write for 49erscap.com. His first published article was in January of 2022 with 49ersCap, and he currently writes and produces weekly podcasts.
All articles by Wayne "Breezie" Brown
Wayne "Breezie" Brown
Wayne Breezie is a 49ers content creator. He had his first guest appearance on Ronbosports in 2012. He began writing for a Facebook group called the League of the 49ers. Next, he began writing for Nothing But Niners in 2017. In 2018, Wayne Breezie made his debut on YouTube’s Nothing But Niners show. In 2019, he started his podcast called Nitty Gritty Niners. After putting the pen down for several years, Breezie saw an opportunity to write for 49erscap.com. His first published article was in January of 2022 with 49ersCap, and he currently writes and produces weekly podcasts.
All articles by Wayne "Breezie" Brown
Related News
More San Francisco 49ers News
-
Netflix to stream 49ers vs. Rams Week 1 international showdown in Australia
The San Francisco 49ers will open the 2026 season on a global stage, as their Week 1 matchup against the Los Angeles Rams is reportedly set to stream on Netflix from Melbourne, Australia, according to Andrew Marchand of The Athletic. NEWS 🏈: Netflix will have the Week... -
Expert links former 49ers star to NFC West rival as best fit
Surprisingly, former San Francisco 49ers wide receiver Jauan Jennings remains available in free agency, continuing to wait for the right opportunity and a competitive contract. Meanwhile, the 49ers appear to have moved on. San Francisco has reshaped its wide receiver room this... -
49ers vs. Vikings: NFL officially announces 2026 Mexico City matchup
The NFL officially announced that the San Francisco 49ers will host the Minnesota Vikings in a Week 11 matchup at the iconic Estadio Banorte in Mexico City on Sunday, November 22, 2026. The game will serve as NBC's Sunday Night Football matchup, with kickoff scheduled for 5:20... -
Daniel Jeremiah ranks 49ers draft value last among NFL teams
NFL Media draft analyst Daniel Jeremiah ranked all 32 NFL draft classes based on the value each team received from its selections, and the San Francisco 49ers landed at the bottom of the list at No. 32. Jeremiah's rankings were based on where each player appeared within his...