49ers vs. Cardinals in Week 3: How to watch, stream, and listen, plus odds

The San Francisco 49ers return to Levi's Stadium for their first home game of the season, taking on the Arizona Cardinals. This matchup marks the 68th all-time meeting between the two teams, with the 49ers leading the series 36-31 and aiming to improve to 21-15 at home against Arizona.

Previous game

The 49ers are coming off a 26-21 victory over the New Orleans Saints. The offense was led by QB Mac Jones, who completed 26 of 39 passes for 279 yards and three touchdowns. WR Jauan Jennings recorded five catches for a team-high 89 yards, including a 42-yard touchdown, while TE Luke Farrell had two receptions for 15 yards and an 11-yard touchdown. RB Christian McCaffrey contributed 13 carries for 55 yards on the ground, along with six receptions for 52 yards and a seven-yard touchdown through the air.

On defense, San Francisco sacked Saints QB Spencer Rattler three times and forced one takeaway. LB Fred Warner led the unit with 11 tackles, one pass defensed, one forced fumble, and one fumble recovery. DL Nick Bosa added a career-high nine tackles and a sack, while DL Bryce Huff recorded four tackles, a forced fumble, and a sack. CB Upton Stout contributed five tackles and notched the first sack of his career.

Below is everything you need to know to follow the upcoming game.

When does the game start?

Sunday, September 21 at 1:25 p.m. PT

Where is the game being played?

Levi's Stadium in Santa Clara, California

Who are the head coaches?

49ers: Kyle Shanahan
Cardinals: Jonathan Gannon

Betting Odds

As of September 17, the 49ers are favored by 1.5 points in this game, with an over/under set at 43.5 points, per BetMGM.

What channel is the game on?

Network: FOX
Play-By-Play: Adam Amin
Color Analyst: Mark Sanchez
Sideline Reporter: Kristina Pink

Viewers outside the broadcast area can watch the game via NFL Sunday Ticket on YouTube TV or YouTube Premium, but a subscription to the package is required.

What areas will receive the broadcast?

The broadcast will be viewable within the markets designated below (plus Hawaii) for those without NFL Sunday Ticket.

Coverage map courtesy of 506sports.com

Where can I stream the game?

NFL Sunday Ticket subscribers can stream the game using the YouTube TV app. Those who purchased through YouTube Premium can watch via the YouTube app. Additionally, NFL+ subscribers can stream the game in its entirety once the matchup has been completed.

Bay Area fans can stream the game through the official 49ers app or at 49ers.com.

Where can I listen to the radio broadcast?

49ers Radio
Bay Area fans can listen on KGO 810 AM and The Bone 107.7 FM, where Guy Haberman and Tim Ryan will call the game.

Jesús Zárate and Carlos Yustis will call the game in Spanish. Fans can listen at 49ers.com/esp.

Cardinals Radio
Phoenix area fans can listen on Arizona Sports 98.7 FM, where Dave Pasch and A.Q. Shipley will call the game.

National Radio
Fans can listen to the game via ESPN Radio, where Chris Carlin and Kelly Stouffer will provide the call.

Streaming
NFL+ subscribers can listen to the game through that service.

Game discussion

Fans can discuss the game within our Niner Talk forum.

How has this series played out historically?

Matchups: 67
Series Record: 49ers lead series 36-31
49ers Home Record vs. Cardinals: 49ers lead series 20-15
49ers Away Record vs. Cardinals: Series is tied 16-16
First Meeting: 11/18/51, Cardinals win 27-21, at SF*
Last Meeting: 1/5/25, Cardinals win 47-24, at Arz.
Current Streak: Lost 2
Longest 49ers Win Streak: 5 – 3 times (Last 9/13/09 – 11/20/11)
Longest Cardinals Win Streak: 8 – (9/27/15 – 10/28/18)
Most 49ers Points: 56 (10/18/92): 49ers win 56-17, at SF
Most Cardinals Points: 47 (1/5/25): Cardinals win 47-24, at Arz.
49ers Shutouts: None
Cardinals Shutouts: None
* Chicago Cardinals

49ers Notes

QB MAC JONES passed for 279 yards and 3 TDs with 0 INTs for a 113.1 passer rating in his 49ers debut last week. It marked his 2nd career game with 275+ pass yards and 3+ TD passes. Has 20+ completions and 30+ attempts in 6 of his past 7 starts overall.
RB CHRISTIAN McCAFFREY had 6 receptions, 107 scrimmage yards (55 rush, 52 rec.), and his 30th career TD catch in Week 2. Became the 3rd player ever with 50+ career rushing TDs (52) and 30+ career receiving TDs. One of 3 players (James Cook, Bijan Robinson) with 100+ scrimmage yards in each of the first 2 weeks. Can become the first player since HOFer Marshall Faulk (2000) with 50+ rush yards and 50+ receiving yards in each of the first 3 weeks of a season. Has 1,609 scrimmage yards (107.3 per game) and 16 TDs (10 rush, 6 rec.) in 15 home games with SF since 2022. Aims for 6th straight home game with 100+ scrimmage yards. Aims for 3rd straight game vs. Arizona with 175+ scrimmage yards and 3+ TDs. Has 100+ scrimmage yards in 6 of 7 career games vs. Arizona.
RB BRIAN ROBINSON aims for his 3rd straight game vs. Arizona with a TD.
WR JAUAN JENNINGS had 5 catches for a team-high 89 yards and his 1st TD of the season in Week 2. Had 7 catches for 52 yards in last meeting.
WR RICKY PEARSALL aims for his 5th straight game with 50+ receiving yards. Had a TD catch in last meeting.
LB FRED WARNER led team with 11 tackles, plus a TFL, PD, FF, and FR last week. Aims for his 3rd straight game vs. Arizona and 5th straight overall with a TFL.
DL NICK BOSA aims for his 3rd straight game with a sack. Has 35 sacks and 46 TFL in 42 career home games. Had 2 TFL and an INT in last home meeting vs. Arizona.
DL BRYCE HUFF had his 1st sack of the season and 3rd career FF last week.
DL MYKEL WILLIAMS (rookie) recorded his 1st 2 career TFL in Week 2.
CB UPTON STOUT (rookie) tallied his 1st career sack last week.
CB RENARDO GREEN has a PD in 10 of his past 11 games. Aims for his 6th straight game with a PD. Had a career-high 3 PD in last meeting vs. Arizona.

Cardinals Notes

QB KYLER MURRAY totaled 252 yards (220 pass, 32 rush) with a TD pass last week. Aims for his 4th straight game with a 90+ passer rating and 6th straight with a TD pass. Passed for 4 TDs with 0 INTs and a 128.5 rating in last meeting. Aims for his 4th straight game at San Francisco with a rushing TD.
RB JAMES CONNER scored his 60th career rushing TD last week. Aims for his 3rd straight game with a TD. Had 100 scrimmage yards (86 rush, 14 rec.) in last meeting. Has 50+ scrimmage yards in 6 of 7 career games vs. SF.
TE TREY MCBRIDE had 6 catches for 78 yards last week. Has 6+ receptions in 8 of his past 9 games and aims for his 5th straight with 6+ receptions. Had a TD catch in last meeting and aims for his 4th straight game vs. SF with 6+ catches and 50+ receiving yards. Since 2023, has 22 games with 5+ receptions, most among NFL tight ends.
WR MARVIN HARRISON JR. aims for his 3rd straight road game with 5+ catches and 70+ receiving yards. Had 5 receptions for 63 yards and a TD in last meeting.
WR MICHAEL WILSON had his 1st TD catch of the season in Week 2. Had 5 receptions for 78 yards in last road meeting (10/6/24).
DL CALAIS CAMPBELL became the 4th player since 1982 with 2+ sacks in a game at age 39-or-older (joining James Harrison, Clay Matthews, and HOFer Bruce Smith). Has 15 TFL in 19 career games vs. SF.
LB JOSH SWEAT recorded his 1st sack of the season and 8th career forced fumble last week.
LB BARON BROWNING had his 2nd career INT last week. Aims for his 3rd straight game with a TFL.
LB MACK WILSON aims for his 3rd straight game with 8+ tackles and a PD. Had an INT in last road meeting and aims for his 3rd straight game vs. SF with a PD.
LB ZAVEN COLLINS scored his 1st career FR-TD in Week 2. Had a sack and FF in last meeting.
CB DENZEL BURKE (rookie) set a career high with 3 PD in Week 2.
CB WILL JOHNSON (rookie) aims for his 3rd straight game with a PD.
S BUDDA BAKER aims for his 13th straight game vs. SF with 5+ tackles.
S JALEN THOMPSON led the team with 10 tackles in Week 2.

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