Then came the defining moment. Defensive end Nick Bosa broke through, pushing offensive tackle Abraham Lucas into Darnold, causing a fumble and recovering it himself, leaving just 36 seconds remaining and sealing San Francisco's hard-fought 17-13 victory.
"It means a lot," Bosa said after the game. "It was a grind of a game. A lot of ups and downs. It tested us in a lot of ways, so it was really good. Obviously, ending with a win is what we're always aiming for, and the fact that I was able to help, it's always great."
All-Pro linebacker Fred Warner admitted the 49ers' defense wasn't perfect in that moment but credited Bosa for saving the day.
"You'll see it (in the film)," Warner said. "It wasn't the best coverage by our group, but thank God for Bosa in that situation. I saw the ball come out. I didn't know who forced it. I saw him get on it. And so, the fact that he made that big of a play, it was major.
"It wasn't clean at all, all game long, but finding a way to win in the division, Week 1, is major."
Head coach Kyle Shanahan shared the same relief—but immediately had to ensure his own safety on the sideline.
"[I was] pumped up," Shanahan said. "Then I've got to watch out for all the big guys who try to knock me out on the sideline to celebrate after it. They always get much more aggressive than me. But I was pumped.
"In those two-minute situations, you want to go tee off on the quarterback, and from what I saw, it was an awesome job—not just running past him, allowing him to step up. He got to the top. I think he came back underneath, and I don't know if he knocked it out or not, but ... it was huge.
"And just to finish it right there, we don't have to worry about what else would have happened."
Safety Jason Pinnock didn't get to see the fumble live, but was thrilled with the result.
"I was in coverage, so I missed a lot of it," Pinnock said. "I just got excited. I just saw a ball on the ground—that's it. And I saw big Bosa come out with the shrug, so I knew we was good."
Bosa noted the defense wasn't pressing to create a turnover but was grinding through the moment.
"It was a grind all game," Bosa repeated. "They were making it tough, and thankfully, I made a play at the end."
The win not only gave the 49ers a 1-0 start to the 2025 season but also came against a divisional rival in one of the NFL's most challenging road environments.
"It was extra motivation, knowing that it was in the division, it was on the road, Week 1," Warner said. "It's always everything at stake, but you understand, when you've played long enough, how big those division games are. So, the fact that we were able to come on the road and get this win, can't speak enough to it."
For Bosa, it was a reminder of why staying ready is so critical. He added, "You never know when your opportunity is going to come. It's a really tough league. So, whenever you have those opportunities, no matter what's happened before, you've got to be ready."
Up next, the 49ers face another road test on September 14 against the New Orleans Saints as they look to start 2-0 before their home opener.
More San Francisco 49ers News
-
John Lynch: 49ers expect Nick Bosa, key defenders back by training camp
Losing Nick Bosa to a torn ACL in Week 3 dealt a significant blow to the San Francisco 49ers defense, which struggled to generate consistent pressure on opposing quarterbacks throughout the 2025 NFL season. It marked the second ACL injury of Bosa's NFL career, with the first... -
49ers free agency: CBS Sports urges San Francisco to target Joey Bosa
The San Francisco 49ers' pass rush was a major weakness in 2025. The defense totaled just 20 sacks — the fewest in the NFL — creating an urgent need for reinforcements this offseason. If new defensive coordinator Raheem Morris is going to stabilize the unit in his first... -
49ers re-sign OL Nick Zakelj to a one-year extension
The San Francisco 49ers have re-signed offensive lineman Nick Zakelj to a one-year extension, the team announced. Zakelj appeared in three games during the 2025 NFL season after being elevated from the practice squad for each of those matchups. The 49ers Communications staff... -
49ers restore locker room after Seahawks' Super Bowl LX takeover
The San Francisco 49ers locker room at Levi's Stadium looked a little different during Super Bowl LX — and not in a way 49ers players appreciated. Although the Seattle Seahawks were officially designated as the away team, they were assigned the home locker room and even wore...