As usual, the San Francisco 49ers will face each NFC West rival twice. They'll also play the last-place teams from the NFC North (Bears), NFC East (Giants), and AFC North (Browns). Additionally, their schedule features matchups against every team in both the NFC South and the AFC South.
RELATED
The 2025 NFL season will kick off on Thursday, September 4, with the Super Bowl champion Philadelphia Eagles hosting the Dallas Cowboys at Lincoln Financial Field. The season will conclude with Super Bowl LX on February 8, 2026, at Levi's Stadium in Santa Clara, California—home of the 49ers.
San Francisco avoided any international games this season, as the NFL has announced those matchups. They also won't be playing on Thanksgiving or Christmas.
Below is a list of confirmed or reported 49ers games, including known dates, times (if available), and sources. Once the full schedule is officially released, I'll share a complete breakdown in a separate article.
Known Matchup Dates/Times (All Times Pacific)
- Week 1: at Seahawks (Sep. 7, per Dave Mahler)
- Week 2: at Saints (unconfirmed)
- Week 3: vs. Cardinals (Sep. 21, 1:25 p.m., confirmed)
- Week 4: vs. Jaguars (per Dilla, Bold Take Pod)
- Week 5: at Rams (Oct. 2, 5:15 p.m., TNF, @OzzyNFL)
- Week 6: at Buccaneers (unconfirmed)
- Week 7: vs. Falcons (Oct. 19, 5:20 p.m., SNF, confirmed)
- Week 8: at Texans (unconfirmed)
- Week 9: at Giants (Nov. 2, per Art Stapleton)
- Week 10: vs. Rams (Nov. 9, 1:25 p.m., @OzzyNFL)
- Week 11: at Cardinals (unconfirmed)
- Week 12: vs. Panthers (Nov. 24, 5:15 p.m., MNF, Travis Hancock)
- Week 13: at Browns (unconfirmed)
- Week 14: BYE (unconfirmed)
- Week 15: vs. Titans (Dec. 14, 1:25 p.m., confirmed)
- Week 16: at Colts (Dec. 22, MNF, unconfirmed)
- Week 17: vs. Bears (Dec. 28, SNF, confirmed)
- Week 18: vs. Seahawks (Jan. 3 or 4, Corbin K. Smith)
Note: "Unconfirmed" listings should be treated as rumors until an official media member confirms them. Those marked "confirmed" were previously unconfirmed rumors.
Home/Away Opponents
Below are all of San Francisco's home and away opponents for the 2025 season. Those reported above are denoted with a strikethrough.
Home (8)
Arizona CardinalsLos Angeles RamsSeattle SeahawksAtlanta FalconsCarolina PanthersChicago BearsJacksonville JaguarsTennessee Titans
Away (9)
Arizona CardinalsLos Angeles RamsSeattle SeahawksCleveland BrownsHouston TexansIndianapolis ColtsNew Orleans SaintsNew York GiantsTampa Bay Buccaneers
Related News
More San Francisco 49ers News
-
49ers Set to Release Brandon Aiyuk Ahead of Training Camp
The San Francisco 49ers plan to release former star wide receiver Aiyuk in the coming weeks, ending a bitter standoff, according to reports. The San Francisco 49ers are ready to move on from Brandon Aiyuk. The team plans to release the disgruntled wide receiver, NFL insider... -
49ers star Fred Warner names young defensive breakout candidates
San Francisco 49ers star linebacker Fred Warner is preparing to enter his ninth NFL season. Yet it doesn't seem that long ago that he was a newcomer quickly making a name for himself on an evolving 49ers defense. Warner spoke with NBC Sports Bay Area's Jennifer Lee Chan at his... -
49ers All-Pro: 'Mac Jones is a glue guy'
San Francisco 49ers quarterback Mac Jones is entering his second season with the team and has already established himself as a favorite among teammates. Jones appeared in 11 games and made eight starts during his first year with the 49ers, throwing for 2,151 yards, 13... -
49ers rookie Kaelon Black earns strong endorsement from Greg Cosell
There was no shortage of criticism when the San Francisco 49ers used the 90th overall pick of the NFL Draft on running back Kaelon Black. Many analysts and fans viewed the selection as a reach, believing Black was taken much earlier than he should have been. One respected...