As usual, the San Francisco 49ers will face each NFC West rival twice. They'll also play the last-place teams from the NFC North (Bears), NFC East (Giants), and AFC North (Browns). Additionally, their schedule features matchups against every team in both the NFC South and the AFC South.
RELATED
The 2025 NFL season will kick off on Thursday, September 4, with the Super Bowl champion Philadelphia Eagles hosting the Dallas Cowboys at Lincoln Financial Field. The season will conclude with Super Bowl LX on February 8, 2026, at Levi's Stadium in Santa Clara, California—home of the 49ers.
San Francisco avoided any international games this season, as the NFL has announced those matchups. They also won't be playing on Thanksgiving or Christmas.
Below is a list of confirmed or reported 49ers games, including known dates, times (if available), and sources. Once the full schedule is officially released, I'll share a complete breakdown in a separate article.
Known Matchup Dates/Times (All Times Pacific)
- Week 1: at Seahawks (Sep. 7, per Dave Mahler)
- Week 2: at Saints (unconfirmed)
- Week 3: vs. Cardinals (Sep. 21, 1:25 p.m., confirmed)
- Week 4: vs. Jaguars (per Dilla, Bold Take Pod)
- Week 5: at Rams (Oct. 2, 5:15 p.m., TNF, @OzzyNFL)
- Week 6: at Buccaneers (unconfirmed)
- Week 7: vs. Falcons (Oct. 19, 5:20 p.m., SNF, confirmed)
- Week 8: at Texans (unconfirmed)
- Week 9: at Giants (Nov. 2, per Art Stapleton)
- Week 10: vs. Rams (Nov. 9, 1:25 p.m., @OzzyNFL)
- Week 11: at Cardinals (unconfirmed)
- Week 12: vs. Panthers (Nov. 24, 5:15 p.m., MNF, Travis Hancock)
- Week 13: at Browns (unconfirmed)
- Week 14: BYE (unconfirmed)
- Week 15: vs. Titans (Dec. 14, 1:25 p.m., confirmed)
- Week 16: at Colts (Dec. 22, MNF, unconfirmed)
- Week 17: vs. Bears (Dec. 28, SNF, confirmed)
- Week 18: vs. Seahawks (Jan. 3 or 4, Corbin K. Smith)
Note: "Unconfirmed" listings should be treated as rumors until an official media member confirms them. Those marked "confirmed" were previously unconfirmed rumors.
Home/Away Opponents
Below are all of San Francisco's home and away opponents for the 2025 season. Those reported above are denoted with a strikethrough.
Home (8)
Arizona CardinalsLos Angeles RamsSeattle SeahawksAtlanta FalconsCarolina PanthersChicago BearsJacksonville JaguarsTennessee Titans
Away (9)
Arizona CardinalsLos Angeles RamsSeattle SeahawksCleveland BrownsHouston TexansIndianapolis ColtsNew Orleans SaintsNew York GiantsTampa Bay Buccaneers
Related News
More San Francisco 49ers News
-
49ers practice and media schedule ahead of Week 18 matchup vs. Seahawks
The San Francisco 49ers will hold three full practices this week as they prepare for their Week 18 matchup against the Seattle Seahawks. Head coach Kyle Shanahan, defensive coordinator Robert Saleh, offensive coordinator Klay Kubiak, and quarterback Brock Purdy are scheduled... -
Only one 49ers player named to Barnwell's 2025 NFL All-Pro team
ESPN's Bill Barnwell released his 2025 NFL All-Pro team, and only one San Francisco 49ers player earned a spot: veteran left tackle Trent Williams (first-team roster). Helping Williams' cause was his ability to stay healthy this season—mostly. The All-Pro suffered a... -
49ers in Week 18 power rankings: San Francisco rises ahead of NFC West showdown
A lot is at stake in Saturday night's matchup between the San Francisco 49ers and the Seattle Seahawks at Levi's Stadium. The 49ers enter Week 18 coming off a pivotal 42-38 win over the Chicago Bears, while the Seahawks rolled past the Carolina Panthers 27-10. Both teams carry... -
49ers injury updates: Trent Williams, Christian McCaffrey miss practice ahead of Seahawks showdown
San Francisco 49ers head coach Kyle Shanahan offered injury updates on Tuesday as the team turns its attention to the regular-season finale against the Seattle Seahawks. The biggest concern coming out of Sunday night's win over the Chicago Bears was the status of left tackle...