ESPN's Adam Schefter added to that optimism, reporting that Guerendo is expected to play in the primetime matchup.
The 49ers have one final practice—a Saturday afternoon session—before their Week 17 contest at Levi's Stadium. Guerendo has stepped into the starting lineup as injuries have decimated the team's running back group. Christian McCaffrey, Jordan Mason, and Elijah Mitchell are all unavailable.
Drafted in the fourth round, Guerendo has made the most of his opportunities, amassing 381 rushing yards and four touchdowns on 73 carries this season. His impressive 5.2 yards-per-carry underscores his importance as the 49ers look to finish the season on a strong note.
Related News
More San Francisco 49ers News
-
49ers vs. Vikings: NFL officially announces 2026 Mexico City matchup
The NFL officially announced that the San Francisco 49ers will host the Minnesota Vikings in a Week 11 matchup at the iconic Estadio Banorte in Mexico City on Sunday, November 22, 2026. The game will serve as NBC's Sunday Night Football matchup, with kickoff scheduled for 5:20... -
49ers named among NFL's most complete teams entering 2026 season
The San Francisco 49ers worked aggressively this offseason to strengthen their roster and keep pace with the Los Angeles Rams and reigning Super Bowl champion Seattle Seahawks in the NFC West. That effort included revamping the wide receiver room and improving a pass rush that... -
49ers predicted to participate in Thanksgiving triple-header
Once again, the NFL is expected to deliver an enticing Thanksgiving Day slate featuring three marquee matchups. The San Francisco 49ers last played on the holiday in 2023, when they defeated the Seattle Seahawks 31-13 at Lumen Field. With the 2026 NFL schedule set to be... -
Former 49ers safety urges position change for 4th-round draft pick
The San Francisco 49ers appear to have strengthened their secondary with the selection of former Washington and Arizona cornerback Ephesians Prysock in the fourth round of the 2026 NFL Draft. At just over 6-foot-3 with a 6-foot-8½ wingspan, Prysock brings rare size to...