The San Francisco 49ers entered Thursday night's NFC West showdown against the Los Angeles Rams without key players, most notably left tackle Trent Williams, who is sidelined for the fourth straight game with an ankle injury. On defense, standout rookie safety Malik Mustapha was ruled out as he recovers from chest and shoulder injuries.

On a positive note, the 49ers activated linebacker Dre Greenlaw from the physically unable to perform (PUP) list, making him available for the game. Additionally, defensive end Nick Bosa (hip, oblique) and running back Isaac Guerendo (foot sprain), both initially listed as questionable, were cleared to play.


Here are the latest in-game injury updates for the 49ers. This article will be updated as new injuries are reported.

S Ji'Ayir Brown (groin, questionable)


Ji'Ayir Brown exited the game in the second half with a groin injury and is questionable to return.

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