The San Francisco 49ers hit the road for the second consecutive week to face the Buffalo Bills on Sunday Night Football at Highmark Stadium. This matchup marks the 14th all-time meeting between the two teams and the first since the 2020 season. San Francisco aims to improve to 7-7 in the series against Buffalo and 3-0 against AFC East opponents in 2024.

Previous game


The 49ers are coming off a 38-10 loss to the Green Bay Packers. On offense, the Niners were led by tight end George Kittle, who caught all six of his targets for a team-high 82 yards and one touchdown. Quarterback Brandon Allen completed 17 of 29 passing attempts for 199 yards. Wide receiver Jauan Jennings contributed five receptions for 40 yards, while running back Christian McCaffrey added 11 carries for 31 yards on the ground and three receptions for 37 yards.


Defensively, defensive lineman Leonard Floyd recorded four tackles and 2.0 sacks against Packers quarterback Jordan Love. Cornerback Isaac Yiadom and safety Malik Mustapha each registered nine tackles, providing critical support for the 49ers' defense.

Below is everything you need to know to follow the upcoming game.

When does the game start?


Sunday, December 1 at 5:20 p.m. PT

Where is the game being played?


Highmark Stadium in Orchard Park, New York

Who are the head coaches?


49ers: Kyle Shanahan
Bills: Sean McDermott


Betting Odds


As of November 26, the Bills are favored by seven points in this game, with an over/under set at 45 points.

What channel is the game on?


Network: NBC
Play-By-Play: Mike Tirico
Color Analyst: Cris Collinsworth
Sideline Reporter: Melissa Stark

What areas will receive the broadcast?


NBC will broadcast the game nationally.

Where can I stream the game?


You can watch the matchup live on the NBC website, NBC Sports app, NBC Sports website, Peacock TV, or the NBC app. Sunday Night Football will also be available to watch on the Yahoo Sports app and NFL app.

Where can I listen to the radio broadcast?


49ers Radio
Bay Area fans can listen on KGO 810 AM and The Bone 107.7 FM, where Greg Papa and Tim Ryan will call the game.


Jesu?s Za?rate and Carlos Yustis will call the game in Spanish. That broadcast can be heard at 49ers.com/news/Espanol.

Bills Radio
Buffalo area fans can listen on WGR 550, where Chris Brown and Eric Wood will call the game.

National Radio
Fans can listen via Westwood One, where Ryan Radtke and Ross Tucker will call the game.

Streaming
NFL+ subscribers can listen to the game through that service.

Game discussion


Fans can discuss the game within our Niner Talk forum.


How has this series played out historically?


Matchups: 13
Series Record: Bills lead series 7-6
49ers Home Record vs. Bills: Series is tied 4-4
49ers Away Record vs. Bills: Bills lead series 3-2
First Meeting: 9/24/72, Bills win 27-20, at Buf.
Last Meeting: 12/7/20, Bills win 34-24, at SF*
Current Streak: Lost 2
Longest 49ers Win Streak: 2 - 2 times (Last 11/30/08 – 10/7/12)
Longest Bills Win Streak: 2 - 2 times (Last 10/16/16 – 12/7/20)
Most 49ers Points: 45 (10/7/12): 49ers win 45-3, at SF
Most Bills Points: 45 (10/16/16): Bills win 45-16, at Buf.
49ers Shutouts: 12/2/01, 49ers win 35-0, at SF
Bills Shutouts: None
SF* - State Farm Stadium (Arizona)

49ers Notes



Bills Notes




Related News




Follow us on: X, Facebook, Threads, Instagram


More San Francisco 49ers News