The Green Bay Packers will host the San Francisco 49ers at Lambeau Field in Green Bay, Wisconsin, on Sunday, November 24, at 1:25 p.m. PT. Heading into the matchup, the Packers are favored by 5.5 points.

Each week, 49ers Webzone staff members participate in the NFL Pick 'em contest, predicting winners for every NFL game. For Week 12, six out of seven staff members picked the Packers to beat the 49ers, leaving just one confident in San Francisco pulling off the upset.


Among the fans participating in the NFL Pick 'Em contest, 55% have also chosen the Packers to emerge victorious, as of this post, marking the first time fans have favored a 49ers opponent this season. This change is likely influenced by the 49ers ruling out starting quarterback Brock Purdy for the game.

Most One-Sided Matchup: Chiefs at Panthers


Two Week 12 games stand out as the most lopsided in terms of predictions. An overwhelming 98% believe the Kansas City Chiefs will dominate the Carolina Panthers, while the same percentage expects the Houston Texans to triumph over the Tennessee Titans.

Most Competitive Matchup: Cardinals at Seahawks


The closest contest in terms of fan predictions is the NFC West clash between the Arizona Cardinals and the Seattle Seahawks. This matchup is a virtual coin toss, with 50% of participants picking each team.

Week 12 NFL Matchups


Below is a breakdown of all 12 matchups for the upcoming slate of NFL games.

Picks Away Home Picks
87%
Vikings
Bears
13%
97%
Lions
Colts
3%
6%
Patriots
Dolphins
94%
95%
Buccaneers
Giants
5%
7%
Cowboys
Commanders
93%
98%
Chiefs
Panthers
2%
2%
Titans
Texans
98%
85%
Broncos
Raiders
15%
45%
49ers
Packers
55%
50%
Cardinals
Seahawks
50%
79%
Eagles
Rams
21%
62%
Ravens
Chargers
38%


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