Below are the official injury status reports for the two teams.
San Francisco 49ers
Out
RB Christian McCaffrey (calf, Achilles)
Doubtful
S Talanoa Hufanga (knee)
Questionable
LB Dee Winters (ankle)
Minnesota Vikings
Out
WR Jordan Addison (ankle)
Questionable
FS Harrison Smith (hip), OT Brian O'Neill (elbow), G Ed Ingram (tricep)
Notes
Running back Christian McCaffrey was limited in practice on Wednesday and Thursday but did not participate in Friday's session. He missed the Week 1 matchup against the New York Jets and has been working to recover from a calf strain and Achilles tendinitis—injuries that sidelined him for most of training camp and the entire preseason.
The 49ers have ruled Christian McCaffrey out for Week 2. Head coach Kyle Shanahan mentioned that the team is now considering placing the running back on injured reserve, which would sideline him for at least four games.
"It's something we're considering now," Shanahan said. "Yeah, yesterday was his worst day. It's on and off, but with yesterday having the most pain, it's something we're going to be discussing here the next 24 hours."
Safety Talanoa Hufanga, defensive end Yetur Gross-Matos, linebacker Dee Winters, and wide receiver Jauan Jennings all participated in the team's final practice of the week.
Below are Friday's practice participation reports for both the 49ers and Vikings, which were provided by the 49ers Communications staff.
San Francisco 49ers Friday Practice
Did Not Participate In Practice
RB Christian McCaffrey (calf, Achilles)
Limited Participation in Practice
S Talanoa Hufanga (knee), LB Dee Winters (ankle)
Full Participation in Practice
G Aaron Banks (finger, calf), DE Yetur Gross-Matos (knee), WR Jauan Jennings (ankle)
Minnesota Vikings Friday Practice
Did Not Participate In Practice
WR Jordan Addison (ankle), CB Stephon Gilmore (not injury related - rest)
Limited Participation in Practice
FS Harrison Smith (hip), OT Brian O'Neill (elbow), G Ed Ingram (tricep)
Full Participation in Practice
C Garrett Bradbury (knee), WR Jalen Nailor (ankle)
Related News
More San Francisco 49ers News
-
Watch: 49ers RB Christian McCaffrey's offseason workout routine
San Francisco 49ers running back Christian McCaffrey is ramping up his preparation for training camp. He and the team's veterans are scheduled to report to Santa Clara on Saturday, July 25, with the first practice set for the following day. As anticipation builds for the 2026... -
49ers' Christian McCaffrey wins Best Comeback Athlete at the 2026 ESPYS
San Francisco 49ers running back Christian McCaffrey was honored as the Best Comeback Athlete on Wednesday night at the 2026 ESPYS in New York. McCaffrey earned the award over golfer Anthony Kim, Angel City FC defender Savy King, and Texas A&M volleyball standout Kyndal... -
49ers' Brock Purdy left out of ESPN's top-10 quarterback rankings
The debate over where San Francisco 49ers quarterback Brock Purdy ranks among the NFL's elite continues. ESPN's Jeremy Fowler continued his annual NFL position rankings this week, unveiling his list of the league's top quarterbacks. The rankings are based on feedback from NFL... -
Where 49ers' Fred Warner landed in ESPN's off-ball linebacker rankings after injury
San Francisco 49ers linebacker Fred Warner remains one of the NFL's most respected defensive players. Although he missed 11 games last season after suffering a dislocated and fractured right ankle, the All-Pro linebacker still earned the top spot in a prominent offseason...