McCaffrey sat out most of training camp and the entire preseason due to the injuries. Head coach Kyle Shanahan revealed that the player is dealing with Achilles tendinitis, but downplayed the severity, suggesting that McCaffrey would have played had Monday's game been a playoff matchup.
"But when you hear that type of stuff, and it's not a playoff game, and it's Week 1, and especially when you're dealing with the lower extremities like that, it was a tough decision, but hearing all the words and stuff, in the long run, it made it easy," Shanahan said.
The big question remains whether McCaffrey will suit up for Sunday's road game against the Minnesota Vikings, which will be played on artificial turf.
"It feels to me, just taking stock of the situation, talking to people involved, that Christian McCaffrey is a long shot to play this week against the Minnesota Vikings," NFL Media insider Ian Rapoport said on NFL Network.
Most expected McCaffrey to play on Monday, which made the 49ers' decision to list him as inactive just 90 minutes before kickoff surprising.
"I think we all thought, in fact, the 49ers all thought, that Christian McCaffrey was going to shake off a little tightness that he felt late in the week of practice, be able to work out, and be able to play Monday night against the Jets," Rapoport added.
Three days before the game, McCaffrey sounded confident about his availability, hoping to get his usual workload in the regular-season opener. However, after a pregame workout, it was clear he wasn't ready.
Rapoport notes that the Achilles tendinitis seems to be the biggest concern and is requiring the most attention, which is why McCaffrey missed Week 1.
"He is as good as it gets," Rapoport commented. "They want him healthy for the stretch run, so it makes sense for the 49ers to pull back a little bit and ensure when he hits the field again, he is fully healthy."
If McCaffrey is unable to play, the 49ers appear well-prepared. Jordan Mason filled in against the Jets and delivered a career-high 147 rushing yards and a touchdown, averaging 5.3 yards per carry.
Related News
More San Francisco 49ers News
-
Where 49ers RB Christian McCaffrey landed in PFF's top 101 players of 2025
After injuries limited him to just four games in 2024, San Francisco 49ers running back Christian McCaffrey fell off Pro Football Focus' (PFF) Top 101 list. He ensured the absence was short-lived. McCaffrey rebounded in 2025 with a dominant, full 17-game campaign, totaling... -
49ers address long-ignored position in two 2026 NFL mock drafts
The San Francisco 49ers haven't invested significant early-round draft capital in their offensive line in recent years. The last time the team used a first- or second-round pick on an offensive lineman was in 2021, when it selected guard Aaron Banks in the second round. The... -
49ers' George Kittle is PFF's top TE — but can he return to form?
When it comes to elite NFL tight ends, George Kittle of the San Francisco 49ers still sets the standard. According to Pro Football Focus (PFF), Kittle was the highest-graded tight end in 2025, earning a stellar 90.7 offensive grade. Even in an injury-shortened campaign, the... -
Where 49ers QB Brock Purdy landed in PFF's top 101 players of 2025
San Francisco 49ers quarterback Brock Purdy appeared in just nine games during the 2025 NFL season, missing eight contests due to a turf toe injury suffered in Week 1. Still, the former final pick of the 2022 NFL Draft did more than enough to earn recognition from Pro Football...